Product Description: prefoldin, putative
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0016592 | mediator complex |
| Component | GO:0005739 | mitochondrion |
| Process | GO:0045944 | positive regulation of transcription by RNA polymerase II |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | not expressed | N/A | N/A |
| Ring | possibly expressed | 0.03 | 0.99 |
| Trophozoite | expressed | 0.08 | 0.95 |
| Schizont | possibly expressed | 0.01 | 1.00 |
| Gametocyte | not expressed | 0.03 | 0.98 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_1107500
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS *tentative
MIS: 0.126 | MFS: -3.062 | #Insertions: 0
PlasmoGEM Phenotype: N/A
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q8IIS7
"Best" AlphaFill ligand hit: No AlphaFill hits
No associated EC numbersNo evidence of orthology to BindingDB entries
Ortholog Group (OrthoMCL): OG6_103935
Most Similar Human Ortholog: Q9UBK9
TM-align score: 0.85 | RMSD: 1.39
Seq Identity: 0.30 | Length: 139 / 155
All Human Orthologs (OrthoMCL):
| Gene ID | Description |
|---|---|
| ENSG00000126756 | ubiquitously expressed prefoldin like chaperone |
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 2 | 8 | 7 | 9 |
| disruptive | 2 | 10 | 11 | 24 |
| missense | 2 | 10 | 11 | 21 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 4 | 17 | 6 | 10 |
| disruptive | 3 | 30 | 21 | 38 |
| missense | 2 | 28 | 20 | 25 |
PlasmoDB Total SNPs: 177
Non-coding: 171 | Synonymous: 5 | Nonsynonymous: 1 | Stop Codon: 0
Protein Length: 155 | Molecular Weight (kDa): 18.442
UniProt ID(s): Q8IIS7
PDB ID(s): None
Isoelectric Point: 6.26
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR003994 | Ubiquitously expressed transcript protein UXT |
| InterPro | IPR004127 | Prefoldin alpha-like |
| PFam | PF02996 | Prefoldin alpha-like |
| Superfamily | SSF46579 | N/A |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 12368864 | Genome sequence of the human malaria parasite Plasmodium falciparum. | Gardner MJ, Hall N, ..., Barrell B | 10.1038/nature01097 |
| 34494883 | A Prioritized and Validated Resource of Mitochondrial Proteins in PlasmodiumIdentifies Unique Biology. | van Esveld SL, Meerstein-Kessel L, ..., Huynen MA | 10.1128/mSphere.00614-21 |