PF3D7_1107600

Genome location: Pf3D7_11_v3:321,886..325,323(-)

Genome classification: Core

Function and Localization

Product Description: coiled-coil domain-containing protein 40, putative

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB):

Type	GO Term	Name
Component	GO:0005737	cytoplasm

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	not expressed	0.08	0.96
Trophozoite	not expressed	0.05	0.97
Schizont	not expressed	0.03	0.98
Gametocyte	possibly expressed	0.44	0.80

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1107600

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 1 | MFS: 1.162 | #Insertions: 6

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8IIS6

"Best" AlphaFill ligand hit: AN2 (amp phosphoramidate, Local RMSD=0.12) with 3IED (Global RMSD=35.40)

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_104159

Most Similar Human Ortholog: I3L292

TM-align score: 0.39 | RMSD: 4.29

Seq Identity: 0.06 | Length: 68 / 1145

All Human Orthologs (OrthoMCL):

Gene ID	Description
ENSG00000141519	coiled-coil domain containing 40

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	13	70	38	84
disruptive	44	179	98	227
missense	25	138	79	174

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	30	126	64	94
disruptive	110	424	143	391
missense	53	303	113	246

PlasmoDB Total SNPs: 144

Non-coding: 0 | Synonymous: 69 | Nonsynonymous: 75 | Stop Codon: 0

Protein Information

Protein Length: 1145 | Molecular Weight (kDa): 137.462

UniProt ID(s): Q8IIS6

PDB ID(s): None

Isoelectric Point: 9.45

Protein Domain Annotations:

Source	Family ID	Description
InterPro	IPR037386	Coiled-coil domain-containing protein 40
PFam	N/A	N/A
Superfamily	N/A	N/A