Product Description: pescadillo homolog
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0070545 | PeBoW complex |
| Component | GO:0005654 | nucleoplasm |
| Component | GO:0005634 | nucleus |
| Function | GO:0003723 | RNA binding |
| Function | GO:0005515 | protein binding |
| Process | GO:0000463 | maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) |
| Process | GO:0051726 | regulation of cell cycle |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | expressed | N/A | N/A |
| Ring | expressed | 0.72 | 0.65 |
| Trophozoite | expressed | 0.67 | 0.63 |
| Schizont | expressed | 0.16 | 0.90 |
| Gametocyte | expressed | 0.56 | 0.68 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_1107700
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS
MIS: 0.12 | MFS: -3.042 | #Insertions: 0
PlasmoGEM Phenotype: N/A
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q8IIS5
"Best" AlphaFill ligand hit: CQA (amodiaquine, Local RMSD=0.23) with 4FGZ (Global RMSD=18.08)
No associated EC numbersNo evidence of orthology to BindingDB entries
Ortholog Group (OrthoMCL): OG6_102136
Most Similar Human Ortholog: H7BYY8
TM-align score: 0.81 | RMSD: 1.83
Seq Identity: 0.32 | Length: 118 / 643
All Human Orthologs (OrthoMCL):
| Gene ID | Description |
|---|---|
| ENSG00000100029 | pescadillo ribosomal biogenesis factor 1 |
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 8 | 37 | 24 | 47 |
| disruptive | 15 | 96 | 51 | 114 |
| missense | 15 | 92 | 49 | 98 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 15 | 79 | 35 | 49 |
| disruptive | 32 | 206 | 81 | 205 |
| missense | 31 | 173 | 65 | 127 |
PlasmoDB Total SNPs: 116
Non-coding: 54 | Synonymous: 37 | Nonsynonymous: 23 | Stop Codon: 2
Protein Length: 643 | Molecular Weight (kDa): 77.18
UniProt ID(s): A0A144A022, Q8IIS5
PDB ID(s): None
Isoelectric Point: 9.49
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR001357 | BRCT domain |
| InterPro | IPR010613 | Pescadillo |
| InterPro | IPR036420 | BRCT domain superfamily |
| PFam | PF06732 | Pescadillo |
| PFam | PF16589 | BRCT domain |
| Superfamily | SSF52113 | BRCT domain superfamily |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 12368864 | Genome sequence of the human malaria parasite Plasmodium falciparum. | Gardner MJ, Hall N, ..., Barrell B | 10.1038/nature01097 |
| 14698441 | A zinc-binding dual-specificity YVH1 phosphatase in the malaria parasite,Plasmodium falciparum, and its interaction with the nuclear protein, pescadillo. | Kumar R, Musiyenko A, ..., Barik S | https://pubmed.ncbi.nlm.nih.gov/14698441/ |
| 16267556 | A protein interaction network of the malaria parasite Plasmodium falciparum. | LaCount DJ, Vignali M, ..., Hughes RE | 10.1038/nature04104 |
| 23181666 | Organellar proteomics reveals hundreds of novel nuclear proteins in the malariaparasite Plasmodium falciparum. | Oehring SC, Woodcroft BJ, ..., Voss TS | 10.1186/gb-2012-13-11-r108 |