PF3D7_1108000

Genome location: Pf3D7_11_v3:351,860..354,337(+)

Genome classification: Core

Function and Localization

Product Description: IWS1-like protein, putative

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB):

Type	GO Term	Name
Component	GO:0005634	nucleus
Process	GO:2001253	regulation of histone H3-K36 trimethylation
Process	GO:0010793	regulation of mRNA export from nucleus
Process	GO:0050684	regulation of mRNA processing

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	expressed	1.33	0.42
Trophozoite	expressed	1.08	0.45
Schizont	expressed	0.59	0.65
Gametocyte	possibly expressed	1.42	0.33

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1108000

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 1 | MFS: -1.92 | #Insertions: 3

PlasmoGEM Phenotype: Slow (Pb ortholog: PBANKA_0938900)

Relative Growth Rate: 0.82 ± 0.09
Confidence: 6.10

RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_0938900)

Modification: Disrupted | RMgm-2671

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8IIS2

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_132907

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	2	31	13	40
disruptive	36	101	52	108
missense	28	79	41	81

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	4	56	27	39
disruptive	66	187	72	181
missense	44	139	52	105

PlasmoDB Total SNPs: 147

Non-coding: 49 | Synonymous: 53 | Nonsynonymous: 45 | Stop Codon: 0

Protein Information

Protein Length: 568 | Molecular Weight (kDa): 66.547

UniProt ID(s): Q8IIS2

PDB ID(s): None

Isoelectric Point: 8.29

Protein Domain Annotations:

Source	Family ID	Description
InterPro	IPR017923	Transcription factor IIS, N-terminal
InterPro	IPR035441	TFIIS/LEDGF domain superfamily
PFam	PF08711	Transcription factor IIS, N-terminal
Superfamily	SSF47676	TFIIS/LEDGF domain superfamily