PF3D7_1108100

Genome location: Pf3D7_11_v3:355,724..360,711(+)

Genome classification: Core

Function and Localization

Product Description: conserved Plasmodium protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	expressed	N/A	N/A
Ring	expressed	0.10	0.95
Trophozoite	expressed	0.05	0.97
Schizont	expressed	1.34	0.53
Gametocyte	expressed	1.11	0.50

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1108100

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 1 | MFS: -1.799 | #Insertions: 3

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8IIS1

"Best" AlphaFill ligand hit: ABH (2(s)-amino-6-boronohexanoic acid, Local RMSD=0.73) with 3MMR (Global RMSD=38.26)

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_121023

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	12	59	28	97
disruptive	53	207	105	270
missense	32	172	83	216

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	17	130	48	84
disruptive	103	426	203	370
missense	64	336	157	246

PlasmoDB Total SNPs: 370

Non-coding: 80 | Synonymous: 162 | Nonsynonymous: 128 | Stop Codon: 0

Protein Information

Protein Length: 1368 | Molecular Weight (kDa): 162.412

UniProt ID(s): Q8IIS1

PDB ID(s): None

Isoelectric Point: 4.69

Protein Domain Annotations:

Source	Family ID	Description
InterPro	N/A	N/A
PFam	N/A	N/A
Superfamily	N/A	N/A