Product Description: D-tyrosyl-tRNA(Tyr) deacylase
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: 3.1.1.96 (D-aminoacyl-tRNA deacylase)
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0005737 | cytoplasm |
| Function | GO:0051500 | D-tyrosyl-tRNA(Tyr) deacylase activity |
| Function | GO:0106026 | Gly-tRNA(Ala) hydrolase activity |
| Function | GO:0002161 | aminoacyl-tRNA editing activity |
| Process | GO:0006399 | tRNA metabolic process |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | not expressed | N/A | N/A |
| Ring | possibly expressed | 0.12 | 0.94 |
| Trophozoite | possibly expressed | 0.22 | 0.86 |
| Schizont | not expressed | 0.21 | 0.87 |
| Gametocyte | not expressed | 0.38 | 0.78 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_1108200
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS *tentative
MIS: 0.138 | MFS: -3.341 | #Insertions: 0
PlasmoGEM Phenotype: N/A
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q8IIS0
"Best" AlphaFill ligand hit: ADP (adenosine-5'-diphosphate, Local RMSD=0.06) with 3KO3 (Global RMSD=0.47)
BRENDA EC Inhibitors:
| EC # | Name | EC Inhibitors |
|---|---|---|
| 3.1.1.96 | D-aminoacyl-tRNA deacylase | EDTA |
No evidence of orthology to BindingDB entries
Ortholog Group (OrthoMCL): OG6_101644
Most Similar Human Ortholog: A0A2R8YCT7
TM-align score: 0.96 | RMSD: 0.91
Seq Identity: 0.44 | Length: 126 / 164
All Human Orthologs (OrthoMCL):
| Gene ID | Description |
|---|---|
| ENSG00000125821 | D-aminoacyl-tRNA deacylase 1 |
| ENSG00000284776 | novel protein |
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 1 | 3 | 5 | 13 |
| disruptive | 0 | 5 | 4 | 15 |
| missense | 0 | 5 | 4 | 12 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 2 | 12 | 6 | 15 |
| disruptive | 3 | 16 | 12 | 35 |
| missense | 2 | 10 | 10 | 21 |
PlasmoDB Total SNPs: 64
Non-coding: 49 | Synonymous: 13 | Nonsynonymous: 2 | Stop Codon: 0
Protein Length: 164 | Molecular Weight (kDa): 19.205
UniProt ID(s): Q8IIS0
PDB ID(s): 3KNF, 3KNP, 3KO3, 3KO4, 3KO5, 3KO7, 3KO9, 3KOB, 3KOC, 3KOD, 3LMT, 3LMU, 3LMV, 4NBI, 4NBJ, 5J61
Isoelectric Point: 7.86
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR003732 | D-aminoacyl-tRNA deacylase DTD |
| InterPro | IPR023509 | D-aminoacyl-tRNA deacylase-like superfamily |
| PFam | PF02580 | D-aminoacyl-tRNA deacylase DTD |
| Superfamily | SSF69500 | D-aminoacyl-tRNA deacylase-like superfamily |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 12368864 | Genome sequence of the human malaria parasite Plasmodium falciparum. | Gardner MJ, Hall N, ..., Barrell B | 10.1038/nature01097 |
| 20007323 | Ligand-bound structures provide atomic snapshots for the catalytic mechanism ofD-amino acid deacylase. | Bhatt TK, Yogavel M, ..., Sharma A | 10.1074/jbc.M109.038562 |
| 38352129 | Toxoplasma-host endoplasmic reticulum interaction: How T. gondii activatesunfolded protein response and modulates immune response | Cudjoe O, Afful R, Hagan TA | 10.1016/j.crmicr.2024.100223 |