Product Description: endoplasmic reticulum-resident calcium binding protein
SignalP Peptide: MMKINLYKLLCFICVIFLLHKNVVRS
# Transmembrane Domains: 0
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0020036 | Maurer's cleft |
| Component | GO:0005783 | endoplasmic reticulum |
| Component | GO:0020020 | food vacuole |
| Component | GO:0005634 | nucleus |
| Function | GO:0005509 | calcium ion binding |
| Function | GO:0005515 | protein binding |
| Process | GO:0035891 | exit from host cell |
| Process | GO:0006886 | intracellular protein transport |
| Process | GO:0006508 | proteolysis |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | not expressed | N/A | N/A |
| Ring | expressed | 0.87 | 0.64 |
| Trophozoite | expressed | 2.24 | 0.17 |
| Schizont | expressed | 1.25 | 0.52 |
| Gametocyte | expressed | 1.27 | 0.41 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_1108600
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS
MIS: 0.129 | MFS: -3.259 | #Insertions: 0
PlasmoGEM Phenotype: N/A
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q8IIR7
"Best" AlphaFill ligand hit: No AlphaFill hits
No associated EC numbersNo evidence of orthology to BindingDB entries
Ortholog Group (OrthoMCL): OG6_105526
Most Similar Human Ortholog: O43852
TM-align score: 0.55 | RMSD: 4.90
Seq Identity: 0.19 | Length: 237 / 343
All Human Orthologs (OrthoMCL):
| Gene ID | Description |
|---|---|
| ENSG00000128595 | calumenin |
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 3 | 18 | 11 | 16 |
| disruptive | 3 | 17 | 8 | 19 |
| missense | 3 | 16 | 8 | 17 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 6 | 31 | 11 | 23 |
| disruptive | 3 | 31 | 17 | 46 |
| missense | 3 | 25 | 17 | 29 |
PlasmoDB Total SNPs: 122
Non-coding: 112 | Synonymous: 8 | Nonsynonymous: 2 | Stop Codon: 0
Protein Length: 343 | Molecular Weight (kDa): 39.374
UniProt ID(s): Q25793, Q8IIR7, Q9TY81, Q9U460
PDB ID(s): None
Isoelectric Point: 4.25
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR002048 | EF-hand domain |
| InterPro | IPR011992 | EF-hand domain pair |
| InterPro | IPR018247 | EF-Hand 1, calcium-binding site |
| PFam | PF13202 | EF-hand domain |
| PFam | PF13499 | EF-hand domain |
| Superfamily | SSF47473 | EF-hand domain pair |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 9364972 | Identification of an endoplasmic reticulum-resident calcium-binding protein withmultiple EF-hand motifs in asexual stages of Plasmodium falciparum. | La Greca N, Hibbs AR, ..., Tilley L | 10.1016/s0166-6851(97)00134-5 |
| 12368864 | Genome sequence of the human malaria parasite Plasmodium falciparum. | Gardner MJ, Hall N, ..., Barrell B | 10.1038/nature01097 |
| 16267556 | A protein interaction network of the malaria parasite Plasmodium falciparum. | LaCount DJ, Vignali M, ..., Hughes RE | 10.1038/nature04104 |
| 21136929 | Food vacuole proteome of the malarial parasite Plasmodium falciparum. | Lamarque M, Tastet C, ..., Dubremetz JF | 10.1002/prca.200700112 |
| 23061985 | Plasmodium falciparum endoplasmic reticulum-resident calcium binding protein is apossible target of synthetic antimalarial endoperoxides, N-89 and N-251. | Morita M, Sanai H, ..., Kim HS | 10.1021/pr3005315 |
| 30379851 | Identification of Plasmodium falciparum nuclear proteins by mass spectrometry andproposed protein annotation. | Briquet S, Ourimi A, ..., Vaquero C | 10.1371/journal.pone.0205596 |
| 31631203 | A network-based approach reveals novel invasion and Maurer's clefts-relatedproteins in Plasmodium falciparum. | Das D, Krishnan SR, Roy A, Bulusu G | 10.1039/c9mo00124g |
| 32098818 | An Endoplasmic Reticulum C REC Family Protein Regulates the Egress Proteolytic Cascade in Malaria Parasites | Fierro MA, Asady B, ..., Muralidharan V | 10.1128/mBio.03078-19 |
| 32890576 | The endoplasmic reticulum-resident serpentine receptor SR10 has importantfunctions for asexual and sexual blood stage development of Plasmodiumfalciparum. | Njila Tchoufack EJ, Hahnfeld L, ..., Pradel G | 10.1016/j.molbiopara.2020.111315 |