Product Description: heat shock protein J2
SignalP Peptide: N/A
# Transmembrane Domains: 1
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0005783 | endoplasmic reticulum |
| Component | GO:0044164 | host cell cytosol |
| Component | GO:0005634 | nucleus |
| Function | GO:0003723 | RNA binding |
| Function | GO:0005515 | protein binding |
| Function | GO:0051082 | unfolded protein binding |
| Process | GO:0006457 | protein folding |
| Process | GO:0009408 | response to heat |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | expressed | N/A | N/A |
| Ring | expressed | 0.31 | 0.85 |
| Trophozoite | expressed | 0.66 | 0.63 |
| Schizont | expressed | 0.46 | 0.74 |
| Gametocyte | expressed | 0.75 | 0.59 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_1108700
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS
MIS: 0.143 | MFS: -3.27 | #Insertions: 0
PlasmoGEM Phenotype: Essential (Pb ortholog: PBANKA_0938300)
RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_0938300)
Modification: Disrupted | RMgm-5124
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q8IIR6
"Best" AlphaFill ligand hit: No AlphaFill hits
No associated EC numbersNo evidence of orthology to BindingDB entries
Ortholog Group (OrthoMCL): OG6_107903
Most Similar Human Ortholog: H7C1G0
TM-align score: 0.63 | RMSD: 3.88
Seq Identity: 0.12 | Length: 109 / 540
All Human Orthologs (OrthoMCL):
| Gene ID | Description |
|---|---|
| ENSG00000077232 | DnaJ heat shock protein family (Hsp40) member C10 |
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
No passing variants found
PlasmoDB Total SNPs: 295
Non-coding: 266 | Synonymous: 23 | Nonsynonymous: 6 | Stop Codon: 0
Protein Length: 540 | Molecular Weight (kDa): 62.377
PDB ID(s): None
Isoelectric Point: 9.44
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR001623 | DnaJ domain |
| InterPro | IPR013766 | Thioredoxin domain |
| InterPro | IPR018253 | DnaJ domain, conserved site |
| InterPro | IPR036249 | Thioredoxin-like superfamily |
| InterPro | IPR036869 | Chaperone J-domain superfamily |
| PFam | PF00085 | Thioredoxin domain |
| PFam | PF00226 | DnaJ domain |
| Superfamily | SSF46565 | Chaperone J-domain superfamily |
| Superfamily | SSF52833 | Thioredoxin-like superfamily |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 12368864 | Genome sequence of the human malaria parasite Plasmodium falciparum. | Gardner MJ, Hall N, ..., Barrell B | 10.1038/nature01097 |
| 16267556 | A protein interaction network of the malaria parasite Plasmodium falciparum. | LaCount DJ, Vignali M, ..., Hughes RE | 10.1038/nature04104 |
| 19294420 | Return to sender: use of Plasmodium ER retrieval sequences to study proteintransport in the infected erythrocyte and predict putative ER protein families. | Kulzer S, Gehde N, Przyborski JM | 10.1007/s00436-009-1397-x |
| 28322872 | Plasmodium Hsp40 and human Hsp70: A potential cochaperone-chaperone complex. | Jha P, Laskar S, ..., Bhattacharyya S | 10.1016/j.molbiopara.2017.03.003 |
| 30379851 | Identification of Plasmodium falciparum nuclear proteins by mass spectrometry andproposed protein annotation. | Briquet S, Ourimi A, ..., Vaquero C | 10.1371/journal.pone.0205596 |
| 33906926 | Functional Characterization of the m(6)A-Dependent Translational Modulator PfYTH | Sinha A, Baumgarten S, ..., Scherf A | 10.1128/mBio.00661-21 |
| 33534803 | A redox-active crosslinker reveals an essential and inhibitable oxidative foldingnetwork in the endoplasmic reticulum of malaria parasites | Cobb DW, Kudyba HM, ..., Muralidharan V | 10.1371/journal.ppat.1009293 |