PF3D7_1108800

Genome location: Pf3D7_11_v3:377,740..378,396(+)

Genome classification: Core

Function and Localization

Product Description: conserved Plasmodium protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	not expressed	0.01	0.99
Trophozoite	not expressed	0.03	0.98
Schizont	not expressed	0.01	0.99
Gametocyte	not expressed	0.14	0.92

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1108800

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS *tentative

MIS: 0.449 | MFS: -3.306 | #Insertions: 0

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8IIR5

"Best" AlphaFill ligand hit: ADP (adenosine-5'-diphosphate, Local RMSD=1.13) with 8BNS (Global RMSD=19.04)

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_532322

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	0	10	4	6
disruptive	5	19	19	36
missense	5	18	19	35

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	0	17	4	13
disruptive	9	59	29	50
missense	8	49	20	38

PlasmoDB Total SNPs: 12

Non-coding: 8 | Synonymous: 2 | Nonsynonymous: 2 | Stop Codon: 0

Protein Information

Protein Length: 155 | Molecular Weight (kDa): 18.655

UniProt ID(s): Q8IIR5

PDB ID(s): None

Isoelectric Point: 6.47

Protein Domain Annotations:

Source	Family ID	Description
InterPro	N/A	N/A
PFam	N/A	N/A
Superfamily	N/A	N/A