PF3D7_1108900

Genome location: Pf3D7_11_v3:378,740..380,796(+)

Genome classification: Core

Function and Localization

Product Description: tetratricopeptide repeat protein, putative

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	possibly expressed	0.15	0.92
Trophozoite	possibly expressed	0.19	0.89
Schizont	not expressed	0.04	0.98
Gametocyte	not expressed	0.33	0.81

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1108900

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.359 | MFS: -2.431 | #Insertions: 0

PlasmoGEM Phenotype: Slow (Pb ortholog: PBANKA_0938100)

Relative Growth Rate: 0.25 ± 0.15
Confidence: 5.21

RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_0938100)

Modification: Disrupted | RMgm-2667

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8IIR4

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_102484

Most Similar Human Ortholog: O95801

TM-align score: 0.55 | RMSD: 5.71

Seq Identity: 0.19 | Length: 313 / 463

All Human Orthologs (OrthoMCL):

Gene ID	Description
ENSG00000243725	tetratricopeptide repeat domain 4

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	8	19	21	37
disruptive	12	72	43	109
missense	9	60	41	94

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	11	58	30	32
disruptive	31	185	75	153
missense	17	158	62	96

PlasmoDB Total SNPs: 124

Non-coding: 74 | Synonymous: 32 | Nonsynonymous: 18 | Stop Codon: 0

Protein Information

Protein Length: 463 | Molecular Weight (kDa): 55.433

UniProt ID(s): Q8IIR4

PDB ID(s): None

Isoelectric Point: 6.04

Protein Domain Annotations:

Source	Family ID	Description
InterPro	IPR011990	Tetratricopeptide-like helical domain superfamily
PFam	N/A	N/A
Superfamily	SSF48452	Tetratricopeptide-like helical domain superfamily