PF3D7_1109100

Genome location: Pf3D7_11_v3:382,557..387,277(-)

Genome classification: Core

Function and Localization

Product Description: conserved Plasmodium protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 1

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	no data	N/A	N/A
Ring	no data	0.14	0.93
Trophozoite	no data	0.06	0.97
Schizont	no data	0.03	0.98
Gametocyte	no data	0.98	0.59

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1109100

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 1 | MFS: 0.102 | #Insertions: 12

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8IIR3

"Best" AlphaFill ligand hit: FMN (flavin mononucleotide, Local RMSD=0.14) with 1TV5 (Global RMSD=36.91)

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_532743

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	15	50	38	99
disruptive	78	193	110	311
missense	45	166	94	256

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	21	123	71	118
disruptive	133	440	193	419
missense	71	357	163	302

PlasmoDB Total SNPs: 210

Non-coding: 28 | Synonymous: 99 | Nonsynonymous: 81 | Stop Codon: 2

Protein Information

Protein Length: 1467 | Molecular Weight (kDa): 175.053

UniProt ID(s): Q8IIR3

PDB ID(s): None

Isoelectric Point: 7.89

Protein Domain Annotations:

Source	Family ID	Description
InterPro	N/A	N/A
PFam	N/A	N/A
Superfamily	N/A	N/A