PF3D7_1109200

Genome location: Pf3D7_11_v3:387,748..389,620(-)

Genome classification: Core

Function and Localization

Product Description: conserved Plasmodium protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	no data	N/A	N/A
Ring	no data	0.09	0.95
Trophozoite	no data	0.10	0.94
Schizont	no data	0.02	0.99
Gametocyte	no data	0.33	0.81

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1109200

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.318 | MFS: -2.449 | #Insertions: 0

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: C6S3E7

"Best" AlphaFill ligand hit: HEM (heme, Local RMSD=0.81) with 7OW9 (Global RMSD=52.81)

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_532604

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	7	23	12	23
disruptive	3	35	19	58
missense	3	31	18	55

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	9	43	21	26
disruptive	9	77	43	88
missense	4	67	38	68

PlasmoDB Total SNPs: 103

Non-coding: 82 | Synonymous: 18 | Nonsynonymous: 3 | Stop Codon: 0

Protein Information

Protein Length: 385 | Molecular Weight (kDa): 46.507

UniProt ID(s): C6S3E7

PDB ID(s): None

Isoelectric Point: 5.63

Protein Domain Annotations:

Source	Family ID	Description
InterPro	N/A	N/A
PFam	N/A	N/A
Superfamily	N/A	N/A