Product Description: essential nuclear protein 1, putative
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0005737 | cytoplasm |
| Component | GO:0005730 | nucleolus |
| Component | GO:0005634 | nucleus |
| Component | GO:0030688 | preribosome, small subunit precursor |
| Function | GO:0030515 | snoRNA binding |
| Process | GO:0006364 | rRNA processing |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | possibly expressed | N/A | N/A |
| Ring | expressed | 0.93 | 0.57 |
| Trophozoite | expressed | 0.68 | 0.63 |
| Schizont | expressed | 0.13 | 0.92 |
| Gametocyte | expressed | 0.84 | 0.55 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_1109400
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS
MIS: 0.38 | MFS: 0 | #Insertions: 0
PlasmoGEM Phenotype: Essential (Pb ortholog: PBANKA_0937800)
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q8IIR2
"Best" AlphaFill ligand hit: No AlphaFill hits
No associated EC numbersNo evidence of orthology to BindingDB entries
Ortholog Group (OrthoMCL): OG6_102261
Most Similar Human Ortholog: Q13895
TM-align score: 0.63 | RMSD: 3.50
Seq Identity: 0.32 | Length: 303 / 436
All Human Orthologs (OrthoMCL):
| Gene ID | Description |
|---|---|
| ENSG00000112578 | bystin like |
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 3 | 34 | 6 | 31 |
| disruptive | 7 | 51 | 24 | 72 |
| missense | 7 | 49 | 22 | 64 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 8 | 51 | 17 | 33 |
| disruptive | 21 | 101 | 54 | 115 |
| missense | 13 | 92 | 45 | 76 |
PlasmoDB Total SNPs: 258
Non-coding: 235 | Synonymous: 13 | Nonsynonymous: 10 | Stop Codon: 0
Protein Length: 436 | Molecular Weight (kDa): 51.704
UniProt ID(s): Q8IIR2
PDB ID(s): None
Isoelectric Point: 9.35
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR007955 | Bystin |
| PFam | PF05291 | Bystin |
| Superfamily | N/A | N/A |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 12368864 | Genome sequence of the human malaria parasite Plasmodium falciparum. | Gardner MJ, Hall N, ..., Barrell B | 10.1038/nature01097 |
| 21279405 | Structural characterization of extracellular polysaccharides produced by themarine fungus Epicoccum nigrum JJY-40 and their antioxidant activities | Sun HH, Mao WJ, ..., Yang YP | 10.1007/s10126-011-9368-5 |
| 20805244 | Analysis of two human pre-ribosomal factors, bystin and hTsr1, highlightsdifferences in evolution of ribosome biogenesis between yeast and mammals | Carron C, O'Donohue MF, ..., Gleizes PE | 10.1093/nar/gkq734 |
| 32408794 | Role of the 40S beak ribosomal protein eS12 in ribosome biogenesis and functionin Saccharomyces cerevisiae | Martin-Villanueva S, Fernandez-Fernandez J, ..., de La Cruz J | 10.1080/15476286.2020.1767951 |
| 29155690 | Cryo-EM structure of a late pre-40S ribosomal subunit from Saccharomycescerevisiae | Heuer A, Thomson E, ..., Beckmann R | 10.7554/eLife.30189 |