About Gene List

PF3D7_1109900 (RPL36)

Genome location: Pf3D7_11_v3:396,205..398,339(+)

Genome classification: Core

Function and Localization

Product Description: 60S ribosomal protein L36

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB):

Type GO Term Name
Component GO:0022625 cytosolic large ribosomal subunit
Component GO:0005634 nucleus
Function GO:0003735 structural constituent of ribosome
Process GO:0002181 cytoplasmic translation
Process GO:0006412 translation

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage LR class MCA mean MCA prop. zeros
Sporozoite possibly expressed N/A N/A
Ring expressed 2.02 0.24
Trophozoite expressed 1.77 0.26
Schizont expressed 0.52 0.70
Gametocyte possibly expressed 0.80 0.59

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1109900

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS *tentative

MIS: 0.122 | MFS: -2.914 | #Insertions: 0

PlasmoGEM Phenotype: Essential (Pb ortholog: PBANKA_0937700)

  • Relative Growth Rate: 0.12 ± 0.37
  • Confidence: 3.37

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8I713

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_101322

Most Similar Human Ortholog: Q9Y3U8

TM-align score: 0.86 | RMSD: 1.42

Seq Identity: 0.43 | Length: 99 / 112

All Human Orthologs (OrthoMCL):

Gene ID Description
ENSG00000130255 ribosomal protein L36

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

No passing variants found

PlasmoDB Total SNPs: 101

Non-coding: 92 | Synonymous: 7 | Nonsynonymous: 2 | Stop Codon: 0

Protein Information

Protein Length: 112 | Molecular Weight (kDa): 12.787

UniProt ID(s): Q8I713

PDB ID(s): 3J79, 3JBN, 3JBO, 3JBP, 5UMD

Isoelectric Point: 11.74

Protein Domain Annotations:

Source Family ID Description
InterPro IPR000509 Ribosomal protein L36e
PFam PF01158 Ribosomal protein L36e
Superfamily N/A N/A

Associated Publications

PMID Title Authors DOI/Link
12368864 Genome sequence of the human malaria parasite Plasmodium falciparum. Gardner MJ, Hall N, ..., Barrell B 10.1038/nature01097
24913268 Cryo-E M structure of the Plasmodium falciparum 80 S ribosome bound to theanti-protozoan drug emetine Wong W, Bai XC, ..., Scheres SH 10.7554/eLife.03080
30379851 Identification of Plasmodium falciparum nuclear proteins by mass spectrometry andproposed protein annotation. Briquet S, Ourimi A, ..., Vaquero C 10.1371/journal.pone.0205596
37655454 Long non-coding RNA and ribosomal protein genes in a yeast ageing model: aninvestigation for undergraduate research-based learning Hwang GH, Clyne RK 10.1042/EBC20230010