PF3D7_1110100 (C2DMA)

Genome location: Pf3D7_11_v3:400,063..403,317(+)

Genome classification: Core

Function and Localization

Product Description: C2 domain-containing membrane protein

SignalP Peptide: N/A

# Transmembrane Domains: 4

EC Numbers: None

Curated GO (PlasmoDB):

Type	GO Term	Name
Component	GO:0009986	cell surface
Function	GO:0005509	calcium ion binding
Function	GO:0046812	host cell surface binding
Process	GO:0044409	entry into host

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	possibly expressed	N/A	N/A
Ring	expressed	0.22	0.89
Trophozoite	expressed	0.39	0.76
Schizont	expressed	0.85	0.55
Gametocyte	expressed	0.40	0.77

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1110100

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.128 | MFS: -2.914 | #Insertions: 0

PlasmoGEM Phenotype: Dispensable (Pb ortholog: PBANKA_0937500)

Relative Growth Rate: 1.03 ± 0.16
Confidence: 5.05

RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_0937500)

Modification: Disrupted | RMgm-2665

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: A0A143ZYA8

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_121156

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	9	51	20	61
disruptive	49	141	77	165
missense	20	95	60	133

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	17	92	34	61
disruptive	84	280	120	227
missense	35	197	94	161

PlasmoDB Total SNPs: 162

Non-coding: 47 | Synonymous: 61 | Nonsynonymous: 54 | Stop Codon: 0

Protein Information

Protein Length: 850 | Molecular Weight (kDa): 101.202

UniProt ID(s): A0A143ZYA8

PDB ID(s): None

Isoelectric Point: 4.85

Protein Domain Annotations:

Source	Family ID	Description
InterPro	IPR000008	C2 domain
PFam	PF00168	C2 domain
Superfamily	SSF49562	N/A

PMID	Title	Authors	DOI/Link
12368864	Genome sequence of the human malaria parasite Plasmodium falciparum.	Gardner MJ, Hall N, ..., Barrell B	10.1038/nature01097
35995671	A C2 domain containing plasma membrane protein of Plasmodium falciparummerozoites mediates calcium-dependent binding and invasion to host erythrocytes.	Munjal A, Kannan D, Singh S	10.1016/j.jmii.2022.07.008