PF3D7_1110300

Genome location: Pf3D7_11_v3:409,782..412,622(-)

Genome classification: Core

Function and Localization

Product Description: G-patch domain-containing protein, putative

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	possibly expressed	N/A	N/A
Ring	possibly expressed	0.43	0.79
Trophozoite	possibly expressed	0.38	0.77
Schizont	possibly expressed	0.09	0.94
Gametocyte	possibly expressed	0.32	0.81

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1110300

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 1 | MFS: -1.823 | #Insertions: 1

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8IIQ9

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_113378

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	doubleton	singleton
synonymous	0	0	1
disruptive	1	2	1
missense	0	0	0

Any inclusion in genotype call

variant type	common	rare
synonymous	0	1
disruptive	1	3
missense	0	0

PlasmoDB Total SNPs: 165

Non-coding: 121 | Synonymous: 26 | Nonsynonymous: 18 | Stop Codon: 0

Protein Information

Protein Length: 221 | Molecular Weight (kDa): 25.881

UniProt ID(s): Q8IIQ9

PDB ID(s): None

Isoelectric Point: 10.21

Protein Domain Annotations:

Source	Family ID	Description
InterPro	IPR000467	G-patch domain
PFam	PF01585	G-patch domain
Superfamily	N/A	N/A