Product Description: ribosomal protein L11, mitochondrial, putative
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0015934 | large ribosomal subunit |
| Component | GO:0005762 | mitochondrial large ribosomal subunit |
| Component | GO:0005739 | mitochondrion |
| Component | GO:0000315 | organellar large ribosomal subunit |
| Component | GO:0005840 | ribosome |
| Function | GO:0070180 | large ribosomal subunit rRNA binding |
| Function | GO:0019843 | rRNA binding |
| Function | GO:0003735 | structural constituent of ribosome |
| Process | GO:0000027 | ribosomal large subunit assembly |
| Process | GO:0006412 | translation |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | expressed | N/A | N/A |
| Ring | possibly expressed | 0.03 | 0.98 |
| Trophozoite | expressed | 0.30 | 0.81 |
| Schizont | expressed | 0.33 | 0.78 |
| Gametocyte | expressed | 0.32 | 0.81 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_1110600
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS
MIS: 0.121 | MFS: -3.06 | #Insertions: 0
PlasmoGEM Phenotype: Essential (Pb ortholog: PBANKA_0937000)
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q8IIQ5
"Best" AlphaFill ligand hit: No AlphaFill hits
No associated EC numbersNo evidence of orthology to BindingDB entries
Ortholog Group (OrthoMCL): OG6_100842
Most Similar Human Ortholog: Q9Y3B7
TM-align score: 0.82 | RMSD: 2.67
Seq Identity: 0.32 | Length: 167 / 178
All Human Orthologs (OrthoMCL):
| Gene ID | Description |
|---|---|
| ENSG00000174547 | mitochondrial ribosomal protein L11 |
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 0 | 0 | 1 | 0 |
| disruptive | 0 | 0 | 0 | 0 |
| missense | 0 | 0 | 0 | 0 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 0 | 1 | 0 | 0 |
| disruptive | 0 | 0 | 0 | 0 |
| missense | 0 | 0 | 0 | 0 |
PlasmoDB Total SNPs: 98
Non-coding: 80 | Synonymous: 13 | Nonsynonymous: 5 | Stop Codon: 0
Protein Length: 178 | Molecular Weight (kDa): 20.479
UniProt ID(s): Q8IIQ5
PDB ID(s): None
Isoelectric Point: 10.83
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR000911 | Ribosomal protein L11/L12 |
| InterPro | IPR020783 | Ribosomal protein L11, C-terminal |
| InterPro | IPR020784 | Ribosomal protein L11, N-terminal |
| InterPro | IPR036769 | Ribosomal protein L11, C-terminal domain superfamily |
| InterPro | IPR036796 | Ribosomal protein L11/L12, N-terminal domain superfamily |
| PFam | PF00298 | Ribosomal protein L11, C-terminal |
| PFam | PF03946 | Ribosomal protein L11, N-terminal |
| Superfamily | SSF46906 | Ribosomal protein L11, C-terminal domain superfamily |
| Superfamily | SSF54747 | Ribosomal protein L11/L12, N-terminal domain superfamily |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 12368864 | Genome sequence of the human malaria parasite Plasmodium falciparum. | Gardner MJ, Hall N, ..., Barrell B | 10.1038/nature01097 |
| 34494883 | A Prioritized and Validated Resource of Mitochondrial Proteins in PlasmodiumIdentifies Unique Biology. | van Esveld SL, Meerstein-Kessel L, ..., Huynen MA | 10.1128/mSphere.00614-21 |