Product Description: actin-like protein, putative
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0005634 | nucleus |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | expressed | N/A | N/A |
| Ring | possibly expressed | 0.01 | 0.99 |
| Trophozoite | expressed | 0.05 | 0.96 |
| Schizont | expressed | 0.14 | 0.90 |
| Gametocyte | expressed | 0.06 | 0.96 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_1110700
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS
MIS: 0.385 | MFS: -2.459 | #Insertions: 0
PlasmoGEM Phenotype: Slow (Pb ortholog: PBANKA_0936900)
RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_0936900)
Modification: Disrupted | RMgm-2660
More info: PhenoPlasm Link
AlphaFill Uniprot ID: A0A143ZXR3
"Best" AlphaFill ligand hit: TAD (beta-methylene-thiazole-4-carboxyamide-adenine dinucleotide, Local RMSD=0.13) with 3BUZ (Global RMSD=2.18)
No associated EC numbersNo evidence of orthology to BindingDB entries
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 3 | 24 | 11 | 24 |
| disruptive | 4 | 20 | 10 | 30 |
| missense | 3 | 20 | 10 | 25 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 7 | 38 | 22 | 30 |
| disruptive | 8 | 57 | 31 | 84 |
| missense | 4 | 48 | 27 | 62 |
PlasmoDB Total SNPs: 162
Non-coding: 145 | Synonymous: 13 | Nonsynonymous: 4 | Stop Codon: 0
Protein Length: 378 | Molecular Weight (kDa): 42.479
UniProt ID(s): A0A143ZXR3
PDB ID(s): None
Isoelectric Point: 4.57
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR004000 | Actin family |
| InterPro | IPR004001 | Actin, conserved site |
| InterPro | IPR043129 | ATPase, nucleotide binding domain |
| PFam | PF00022 | Actin family |
| Superfamily | SSF53067 | ATPase, nucleotide binding domain |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 12368864 | Genome sequence of the human malaria parasite Plasmodium falciparum. | Gardner MJ, Hall N, ..., Barrell B | 10.1038/nature01097 |
| 30379851 | Identification of Plasmodium falciparum nuclear proteins by mass spectrometry andproposed protein annotation. | Briquet S, Ourimi A, ..., Vaquero C | 10.1371/journal.pone.0205596 |
| 36067651 | Amomum longiligulare polysaccharide 1- PLGA nanoparticle promotes the immuneactivities of T lymphocytes and dendritic cells | Wu H, Chen H, ..., Chen Y | 10.1016/j.intimp.2022.109204 |