PF3D7_1110800

Genome location: Pf3D7_11_v3:429,897..431,828(-)

Genome classification: Core

Function and Localization

Product Description: conserved Plasmodium protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	no data	N/A	N/A
Ring	no data	0.01	0.99
Trophozoite	no data	0.06	0.96
Schizont	no data	0.05	0.97
Gametocyte	no data	0.98	0.51

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1110800

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.121 | MFS: -3.226 | #Insertions: 0

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: C6S3E9

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_104978

Most Similar Human Ortholog: R4GN71

TM-align score: 0.71 | RMSD: 2.15

Seq Identity: 0.08 | Length: 77 / 201

All Human Orthologs (OrthoMCL):

Gene ID	Description
ENSG00000162814	spermatogenesis associated 17

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	rare	doubleton	singleton
synonymous	12	5	9
disruptive	19	18	31
missense	19	16	28

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	2	22	8	11
disruptive	7	54	30	43
missense	3	43	23	35

PlasmoDB Total SNPs: 140

Non-coding: 137 | Synonymous: 2 | Nonsynonymous: 1 | Stop Codon: 0

Protein Information

Protein Length: 201 | Molecular Weight (kDa): 24.676

UniProt ID(s): C6S3E9

PDB ID(s): None

Isoelectric Point: 10.6

Protein Domain Annotations:

Source	Family ID	Description
InterPro	IPR000048	IQ motif, EF-hand binding site
PFam	PF00612	IQ motif, EF-hand binding site
Superfamily	N/A	N/A