PF3D7_1110900

Genome location: Pf3D7_11_v3:431,833..434,308(-)

Genome classification: Core

Function and Localization

Product Description: ES2 protein, putative

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB):

Type	GO Term	Name
Component	GO:0071013	catalytic step 2 spliceosome

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	expressed	N/A	N/A
Ring	expressed	0.58	0.72
Trophozoite	expressed	0.44	0.74
Schizont	expressed	0.23	0.85
Gametocyte	possibly expressed	0.49	0.72

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1110900

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 0.999 | MFS: -2.311 | #Insertions: 2

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8IIQ3

"Best" AlphaFill ligand hit: ANP (phosphoaminophosphonic acid-adenylate ester, Local RMSD=16.19) with 3Q5I (Global RMSD=19.55)

No associated EC numbers

Orthology to BindingDB Entries:

UniProt	Protein Name	Species	Homology Source	BindingDB Ligands
Q96PF2	Testis-specific serine/threonine-protein kinase 2	Homo sapiens	OrthoDB	US8486966, 1CHEMBL2381116Staurosporine, 8Staurosporine, 8...

Orthology Information

Ortholog Group (OrthoMCL): OG6_103502

Most Similar Human Ortholog: F8WEF8

TM-align score: 0.35 | RMSD: 5.43

Seq Identity: 0.18 | Length: 147 / 579

All Human Orthologs (OrthoMCL):

Gene ID	Description
ENSG00000100056	ess-2 splicing factor homolog

Protein Information

Protein Length: 579 | Molecular Weight (kDa): 69.018

UniProt ID(s): Q8IIQ3

PDB ID(s): None

Isoelectric Point: 9.73

Protein Domain Annotations:

Source	Family ID	Description
InterPro	IPR019148	Nuclear protein DGCR14/ESS-2
PFam	PF09751	Nuclear protein DGCR14/ESS-2
Superfamily	N/A	N/A

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	6	25	19	35
disruptive	12	92	55	137
missense	8	85	52	127

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	7	50	23	56
disruptive	27	212	94	203
missense	16	184	81	160

PlasmoDB Total SNPs: 147

Non-coding: 89 | Synonymous: 43 | Nonsynonymous: 15 | Stop Codon: 0

PMID	Title	Authors	DOI/Link
12368864	Genome sequence of the human malaria parasite Plasmodium falciparum.	Gardner MJ, Hall N, ..., Barrell B	10.1038/nature01097
16267556	A protein interaction network of the malaria parasite Plasmodium falciparum.	LaCount DJ, Vignali M, ..., Hughes RE	10.1038/nature04104