Product Description: replication factor C subunit 5, putative
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0005663 | DNA replication factor C complex |
| Component | GO:0005634 | nucleus |
| Function | GO:0003723 | RNA binding |
| Process | GO:0006281 | DNA repair |
| Process | GO:0006260 | DNA replication |
| Process | GO:0006271 | DNA strand elongation involved in DNA replication |
| Process | GO:0006261 | DNA-dependent DNA replication |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | possibly expressed | N/A | N/A |
| Ring | expressed | 0.06 | 0.97 |
| Trophozoite | expressed | 0.36 | 0.77 |
| Schizont | expressed | 0.08 | 0.94 |
| Gametocyte | expressed | 0.29 | 0.82 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_1111100
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS
MIS: 0.12 | MFS: -2.946 | #Insertions: 0
PlasmoGEM Phenotype: Essential (Pb ortholog: PBANKA_0936500)
RMgmDB ABS Phenotype: Not tested (Pb ortholog: PBANKA_0936500)
Modification: Other | RMgm-425
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q8IIQ1
"Best" AlphaFill ligand hit: AGS (phosphothiophosphoric acid-adenylate ester, Local RMSD=0.02) with 1SXJ (Global RMSD=2.97)
No associated EC numbersNo evidence of orthology to BindingDB entries
Ortholog Group (OrthoMCL): OG6_102480
Most Similar Human Ortholog: P40938
TM-align score: 0.93 | RMSD: 1.68
Seq Identity: 0.29 | Length: 343 / 349
All Human Orthologs (OrthoMCL):
| Gene ID | Description |
|---|---|
| ENSG00000133119 | replication factor C subunit 3 |
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 0 | 16 | 12 | 24 |
| disruptive | 0 | 7 | 8 | 17 |
| missense | 0 | 7 | 8 | 16 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 0 | 37 | 16 | 27 |
| disruptive | 1 | 26 | 15 | 41 |
| missense | 0 | 26 | 15 | 30 |
PlasmoDB Total SNPs: 146
Non-coding: 138 | Synonymous: 5 | Nonsynonymous: 2 | Stop Codon: 1
Protein Length: 349 | Molecular Weight (kDa): 40.347
PDB ID(s): None
Isoelectric Point: 9.02
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR027417 | P-loop containing nucleoside triphosphate hydrolase |
| PFam | PF13177 | N/A |
| Superfamily | SSF52540 | P-loop containing nucleoside triphosphate hydrolase |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 12368864 | Genome sequence of the human malaria parasite Plasmodium falciparum. | Gardner MJ, Hall N, ..., Barrell B | 10.1038/nature01097 |
| 23181666 | Organellar proteomics reveals hundreds of novel nuclear proteins in the malariaparasite Plasmodium falciparum. | Oehring SC, Woodcroft BJ, ..., Voss TS | 10.1186/gb-2012-13-11-r108 |
| 33040440 | Plasmodium falciparum replication factor C subunit 1 is involved in genotoxicstress response. | Sheriff O, Yaw A, ..., Preiser PR | 10.1111/cmi.13277 |
| 33906926 | Functional Characterization of the m(6)A-Dependent Translational Modulator PfYTH | Sinha A, Baumgarten S, ..., Scherf A | 10.1128/mBio.00661-21 |