Product Description: transcription elongation regulator 1-like protein, putative
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0005685 | U1 snRNP |
| Component | GO:0071004 | U2-type prespliceosome |
| Function | GO:0003723 | RNA binding |
| Process | GO:0000398 | mRNA splicing, via spliceosome |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | not expressed | N/A | N/A |
| Ring | not expressed | 0.17 | 0.92 |
| Trophozoite | not expressed | 0.36 | 0.78 |
| Schizont | not expressed | 0.04 | 0.98 |
| Gametocyte | not expressed | 0.33 | 0.81 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_1111200
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Mutable in CDS
MIS: 0.813 | MFS: -1.904 | #Insertions: 1
PlasmoGEM Phenotype: Essential (Pb ortholog: PBANKA_0936400)
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q8IIQ0
"Best" AlphaFill ligand hit: 1FL (5-(2,4-difluorophenyl)-2-hydroxy-benzoic acid, Local RMSD=4.82) with 5G48 (Global RMSD=16.12)
No associated EC numbersNo evidence of orthology to BindingDB entries
Ortholog Group (OrthoMCL): OG6_103069
Most Similar Human Ortholog: G3V220
TM-align score: 0.29 | RMSD: 6.72
Seq Identity: 0.09 | Length: 255 / 594
All Human Orthologs (OrthoMCL):
| Gene ID | Description |
|---|---|
| ENSG00000113649 | transcription elongation regulator 1 |
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 3 | 30 | 19 | 40 |
| disruptive | 9 | 82 | 41 | 115 |
| missense | 9 | 80 | 41 | 112 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 9 | 64 | 19 | 44 |
| disruptive | 22 | 174 | 77 | 153 |
| missense | 20 | 161 | 72 | 126 |
PlasmoDB Total SNPs: 94
Non-coding: 54 | Synonymous: 23 | Nonsynonymous: 17 | Stop Codon: 0
Protein Length: 594 | Molecular Weight (kDa): 72.525
UniProt ID(s): Q8IIQ0
PDB ID(s): None
Isoelectric Point: 6.29
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR002713 | FF domain |
| InterPro | IPR036517 | FF domain superfamily |
| InterPro | IPR039726 | Pre-mRNA-processing factor Prp40 |
| PFam | PF01846 | FF domain |
| Superfamily | SSF81698 | FF domain superfamily |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 12368864 | Genome sequence of the human malaria parasite Plasmodium falciparum. | Gardner MJ, Hall N, ..., Barrell B | 10.1038/nature01097 |
| 16267556 | A protein interaction network of the malaria parasite Plasmodium falciparum. | LaCount DJ, Vignali M, ..., Hughes RE | 10.1038/nature04104 |