PF3D7_1111300 (BOS1)

Genome location: Pf3D7_11_v3:442,112..444,385(-)

Genome classification: Core

Function and Localization

Product Description: protein transport protein BOS1, putative

SignalP Peptide: N/A

# Transmembrane Domains: 1

EC Numbers: None

Curated GO (PlasmoDB):

Type	GO Term	Name
Component	GO:0012507	ER to Golgi transport vesicle membrane
Component	GO:0005794	Golgi apparatus
Component	GO:0031201	SNARE complex
Component	GO:0005789	endoplasmic reticulum membrane
Component	GO:0031902	late endosome membrane
Function	GO:0005484	SNAP receptor activity
Function	GO:0000149	SNARE binding
Process	GO:0006896	Golgi to vacuole transport
Process	GO:0006888	endoplasmic reticulum to Golgi vesicle-mediated transport
Process	GO:0006891	intra-Golgi vesicle-mediated transport
Process	GO:0006623	protein targeting to vacuole
Process	GO:0042147	retrograde transport, endosome to Golgi
Process	GO:0006906	vesicle fusion
Process	GO:0048280	vesicle fusion with Golgi apparatus
Process	GO:0016192	vesicle-mediated transport

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	not expressed	0.08	0.96
Trophozoite	expressed	0.20	0.86
Schizont	expressed	0.07	0.95
Gametocyte	not expressed	0.14	0.91

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1111300

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.127 | MFS: -3.041 | #Insertions: 0

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8IIP9

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_102735

Most Similar Human Ortholog: A0A1W2PRH7

TM-align score: 0.81 | RMSD: 1.11

Seq Identity: 0.07 | Length: 42 / 289

All Human Orthologs (OrthoMCL):

Gene ID	Description
ENSG00000108433	golgi SNAP receptor complex member 2
ENSG00000262633	novel protein

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	2	11	12	24
disruptive	2	25	18	37
missense	2	24	18	31

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	4	35	11	23
disruptive	4	59	36	73
missense	3	48	32	53

PlasmoDB Total SNPs: 111

Non-coding: 96 | Synonymous: 11 | Nonsynonymous: 4 | Stop Codon: 0

Protein Information

Protein Length: 289 | Molecular Weight (kDa): 34.076

UniProt ID(s): Q0ZAE7, Q8IIP9

PDB ID(s): None

Isoelectric Point: 9.97

Protein Domain Annotations:

Source	Family ID	Description
InterPro	IPR027027	GOSR2/Membrin/Bos1
PFam	PF12352	N/A
Superfamily	N/A	N/A