PF3D7_1111500

Genome location: Pf3D7_11_v3:445,809..446,947(-)

Genome classification: Core

Function and Localization

Product Description: acylphosphatase, putative

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: 3.6.1.7 (Acylphosphatase)

Curated GO (PlasmoDB):

Type	GO Term	Name
Function	GO:0003998	acylphosphatase activity

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	no data	N/A	N/A
Ring	no data	0.03	0.99
Trophozoite	no data	0.15	0.90
Schizont	no data	0.03	0.98
Gametocyte	no data	0.16	0.90

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1111500

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 1 | MFS: -0.156 | #Insertions: 2

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: C6S3F0

"Best" AlphaFill ligand hit: ANP (phosphoaminophosphonic acid-adenylate ester, Local RMSD=0.92) with 4H3P (Global RMSD=18.34)

BRENDA EC Inhibitors:

EC #	Name	EC Inhibitors
3.6.1.7	acylphosphatase	BRENDA SOAP query unsuccessful

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_101060

Most Similar Human Ortholog: P07311

TM-align score: 0.93 | RMSD: 0.84

Seq Identity: 0.42 | Length: 95 / 129

All Human Orthologs (OrthoMCL):

Gene ID	Description
ENSG00000119640	acylphosphatase 1
ENSG00000170634	acylphosphatase 2

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	0	6	7	13
disruptive	3	9	11	16
missense	3	9	11	15

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	1	18	12	9
disruptive	4	33	11	41
missense	3	26	9	30

PlasmoDB Total SNPs: 67

Non-coding: 61 | Synonymous: 4 | Nonsynonymous: 2 | Stop Codon: 0

Protein Information

Protein Length: 129 | Molecular Weight (kDa): 15.08

UniProt ID(s): C6S3F0

PDB ID(s): None

Isoelectric Point: 10.44

Protein Domain Annotations:

Source	Family ID	Description
InterPro	IPR001792	Acylphosphatase-like domain
InterPro	IPR017968	Acylphosphatase, conserved site
InterPro	IPR020456	Acylphosphatase
InterPro	IPR036046	Acylphosphatase-like domain superfamily
PFam	PF00708	Acylphosphatase-like domain
Superfamily	SSF54975	Acylphosphatase-like domain superfamily