PF3D7_1111600

Genome location: Pf3D7_11_v3:448,912..451,698(+)

Genome classification: Core

Function and Localization

Product Description: endonuclease/exonuclease/phosphatase family protein, putative

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: 3.1.3.56 (Inositol-polyphosphate 5-phosphatase)

Curated GO (PlasmoDB):

Type	GO Term	Name
Function	GO:0004439	phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity
Process	GO:0046855	inositol phosphate dephosphorylation
Process	GO:0046856	phosphatidylinositol dephosphorylation

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	expressed	N/A	N/A
Ring	not expressed	0.01	0.99
Trophozoite	possibly expressed	0.06	0.96
Schizont	not expressed	0.05	0.96
Gametocyte	expressed	0.23	0.86

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1111600

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.122 | MFS: -2.893 | #Insertions: 0

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: A0A143ZZC6

"Best" AlphaFill ligand hit: JMM ([4-(cyclopropanecarbonyl)piperazin-1-yl](furan-2-yl)methanone, Local RMSD=0.23) with 5RWT (Global RMSD=4.73)

BRENDA EC Inhibitors:

EC #	Name	EC Inhibitors
3.1.3.56	inositol-polyphosphate 5-phosphatase	ATPADPAMPSDSEDTACdCl2vanadatephosphateDisulfiramthimerosalTriton X-100Phenylglyoxal...

Orthology to BindingDB Entries:

UniProt	Protein Name	Species	Homology Source	BindingDB Ligands
Q9WVR3	Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2	Rattus	OrthoDB	DULOXETINEVenlafaxine hydrochlorideATOMOXETINE
O15357	Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2		OrthoDB	US9522881, 7'a-1 (L89M52)US9522881, 7'c (Core 95)US9522881, 7'c-1 (L95M52)US9522881, 7'c-2 (L95N79)...
Q6P549	Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2		OrthoDB	CHEMBL4538474
P32019	Type II inositol 1,4,5-trisphosphate 5-phosphatase		OrthoDB	CHEMBL4538474

Orthology Information

Ortholog Group (OrthoMCL): OG6_124640

No human ortholog(s)

Protein Information

Protein Length: 744 | Molecular Weight (kDa): 87.146

UniProt ID(s): A0A143ZZC6

PDB ID(s): None

Isoelectric Point: 9.45

Protein Domain Annotations:

Source	Family ID	Description
InterPro	IPR000300	Inositol polyphosphate-related phosphatase
InterPro	IPR036691	Endonuclease/exonuclease/phosphatase superfamily
PFam	N/A	N/A
Superfamily	SSF56219	Endonuclease/exonuclease/phosphatase superfamily

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	7	42	33	62
disruptive	13	77	38	115
missense	13	76	34	100

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	13	107	27	60
disruptive	34	160	84	182
missense	27	141	74	126

PlasmoDB Total SNPs: 114

Non-coding: 71 | Synonymous: 20 | Nonsynonymous: 23 | Stop Codon: 0