PF3D7_1111700

Genome location: Pf3D7_11_v3:451,922..455,003(-)

Genome classification: Core

Function and Localization

Product Description: conserved Plasmodium protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	possibly expressed	N/A	N/A
Ring	expressed	0.31	0.85
Trophozoite	expressed	0.46	0.73
Schizont	possibly expressed	0.08	0.94
Gametocyte	expressed	0.26	0.85

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1111700

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.129 | MFS: -3.174 | #Insertions: 0

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8IIP6

"Best" AlphaFill ligand hit: ADP (adenosine-5'-diphosphate, Local RMSD=0.71) with 3KO3 (Global RMSD=25.39)

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_533574

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	7	40	23	49
disruptive	31	130	67	164
missense	19	99	58	141

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	14	78	37	60
disruptive	59	249	119	245
missense	30	194	101	178

PlasmoDB Total SNPs: 128

Non-coding: 34 | Synonymous: 62 | Nonsynonymous: 31 | Stop Codon: 1

Protein Information

Protein Length: 800 | Molecular Weight (kDa): 95.651

UniProt ID(s): Q8IIP6

PDB ID(s): None

Isoelectric Point: 9.14

Protein Domain Annotations:

Source	Family ID	Description
InterPro	N/A	N/A
PFam	N/A	N/A
Superfamily	N/A	N/A