PF3D7_1111800

Genome location: Pf3D7_11_v3:455,313..457,030(+)

Genome classification: Core

Function and Localization

Product Description: peptidyl-prolyl cis-trans isomerase, putative

SignalP Peptide: N/A

# Transmembrane Domains: 1

EC Numbers: 5.2.1.8 (Peptidylprolyl isomerase)

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	possibly expressed	N/A	N/A
Ring	not expressed	0.04	0.98
Trophozoite	possibly expressed	0.23	0.85
Schizont	expressed	0.13	0.91
Gametocyte	expressed	0.36	0.79

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1111800

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.687 | MFS: -2.425 | #Insertions: 0

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8IIP5

"Best" AlphaFill ligand hit: AN2 (amp phosphoramidate, Local RMSD=2.82) with 3IED (Global RMSD=16.75)

BRENDA EC Inhibitors:

EC #	Name	EC Inhibitors
5.2.1.8	peptidylprolyl isomerase	ATPNEMSDSPCMBFK506QAEGPKAla-ProjugloneSer-ProGPI-1046RNase T1Rapamycin...

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_119527

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	0	17	11	24
disruptive	2	22	25	47
missense	2	22	23	40

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	0	39	11	24
disruptive	12	71	46	80
missense	7	55	37	47

PlasmoDB Total SNPs: 93

Non-coding: 82 | Synonymous: 6 | Nonsynonymous: 5 | Stop Codon: 0

Protein Information

Protein Length: 355 | Molecular Weight (kDa): 42.7

UniProt ID(s): Q8IIP5

PDB ID(s): None

Isoelectric Point: 9.1

Protein Domain Annotations:

Source	Family ID	Description
InterPro	IPR001440	Tetratricopeptide repeat 1
InterPro	IPR011990	Tetratricopeptide-like helical domain superfamily
InterPro	IPR019734	Tetratricopeptide repeat
PFam	PF00515	Tetratricopeptide repeat 1
Superfamily	SSF48452	Tetratricopeptide-like helical domain superfamily