Product Description: ubiquinone biosynthesis protein COQ4, putative
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0005739 | mitochondrion |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | not expressed | N/A | N/A |
| Ring | not expressed | 0.05 | 0.97 |
| Trophozoite | expressed | 0.21 | 0.86 |
| Schizont | expressed | 0.13 | 0.91 |
| Gametocyte | expressed | 0.31 | 0.82 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_1112200
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS
MIS: 0.166 | MFS: -3.307 | #Insertions: 0
PlasmoGEM Phenotype: Essential (Pb ortholog: PBANKA_0935400)
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q8IIP1
"Best" AlphaFill ligand hit: TBR (dodecabromohexatantalum, Local RMSD=0.01) with 2BVL (Global RMSD=21.22)
No associated EC numbersNo evidence of orthology to BindingDB entries
Ortholog Group (OrthoMCL): OG6_103250
Most Similar Human Ortholog: Q9Y3A0
TM-align score: 0.82 | RMSD: 1.76
Seq Identity: 0.24 | Length: 230 / 355
All Human Orthologs (OrthoMCL):
| Gene ID | Description |
|---|---|
| ENSG00000167113 | coenzyme Q4 |
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 5 | 15 | 11 | 22 |
| disruptive | 1 | 10 | 11 | 21 |
| missense | 1 | 10 | 11 | 21 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 7 | 33 | 17 | 23 |
| disruptive | 2 | 33 | 9 | 54 |
| missense | 2 | 30 | 8 | 39 |
PlasmoDB Total SNPs: 12
Non-coding: 0 | Synonymous: 10 | Nonsynonymous: 1 | Stop Codon: 1
Protein Length: 355 | Molecular Weight (kDa): 43.053
UniProt ID(s): A0A143ZYI5, Q8IIP1
PDB ID(s): None
Isoelectric Point: 9.23
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR007715 | Ubiquinone biosynthesis protein Coq4 |
| InterPro | IPR027540 | Ubiquinone biosynthesis protein Coq4, eukaryotes |
| PFam | PF05019 | Ubiquinone biosynthesis protein Coq4 |
| Superfamily | N/A | N/A |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 12368864 | Genome sequence of the human malaria parasite Plasmodium falciparum. | Gardner MJ, Hall N, ..., Barrell B | 10.1038/nature01097 |
| 34494883 | A Prioritized and Validated Resource of Mitochondrial Proteins in PlasmodiumIdentifies Unique Biology. | van Esveld SL, Meerstein-Kessel L, ..., Huynen MA | 10.1128/mSphere.00614-21 |