About Gene List

PF3D7_1112300

Genome location: Pf3D7_11_v3:471,687..474,753(-)

Genome classification: Core

Function and Localization

Product Description: conserved Plasmodium protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage LR class MCA mean MCA prop. zeros
Sporozoite not expressed N/A N/A
Ring not expressed 0.05 0.97
Trophozoite expressed 0.43 0.74
Schizont expressed 0.10 0.93
Gametocyte not expressed 0.45 0.75

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1112300

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.128 | MFS: -3.134 | #Insertions: 0

PlasmoGEM Phenotype: Essential (Pb ortholog: PBANKA_0935300)

  • Relative Growth Rate: 0.11 ± 0.07
  • Confidence: 6.78

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8IIP0

"Best" AlphaFill ligand hit: TCL (triclosan, Local RMSD=0.97) with 3F4B (Global RMSD=21.69)

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_533284

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type common rare doubleton singleton
synonymous 6 38 27 40
disruptive 21 79 44 109
missense 21 78 42 98

Any inclusion in genotype call

variant type common rare doubleton singleton
synonymous 15 74 29 52
disruptive 36 164 80 148
missense 32 149 71 116

PlasmoDB Total SNPs: 122

Non-coding: 58 | Synonymous: 29 | Nonsynonymous: 35 | Stop Codon: 0

Protein Information

Protein Length: 845 | Molecular Weight (kDa): 102.084

UniProt ID(s): Q8IIP0

PDB ID(s): None

Isoelectric Point: 9.83

Protein Domain Annotations:

Source Family ID Description
InterPro N/A N/A
PFam N/A N/A
Superfamily N/A N/A

Associated Publications

PMID Title Authors DOI/Link
12368864 Genome sequence of the human malaria parasite Plasmodium falciparum. Gardner MJ, Hall N, ..., Barrell B 10.1038/nature01097