PF3D7_1112400

Genome location: Pf3D7_11_v3:475,347..476,522(+)

Genome classification: Core

Function and Localization

Product Description: nucleic acid binding protein, putative

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB):

Type	GO Term	Name
Component	GO:0005634	nucleus
Function	GO:0003697	single-stranded DNA binding

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	not expressed	0.05	0.97
Trophozoite	possibly expressed	0.57	0.67
Schizont	expressed	0.18	0.87
Gametocyte	possibly expressed	0.43	0.75

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1112400

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 0.122 | MFS: -3.514 | #Insertions: 1

PlasmoGEM Phenotype: Essential (Pb ortholog: PBANKA_0702900)

Relative Growth Rate: 0.03 ± 0.07
Confidence: 6.77

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8IIN9

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

Orthology to BindingDB Entries:

UniProt	Protein Name	Species	Homology Source	BindingDB Ligands
Q8X225	Histone-lysine N-methyltransferase, H3 lysine-9 specific dim-5		OrthoMCL	chaetocin
P45975	Histone-lysine N-methyltransferase Su(var)3-9	Drosophila melanogaster	OrthoMCL	chaetocinchaetocinchaetocin

Orthology Information

Ortholog Group (OrthoMCL): OG6_100876

Most Similar Human Ortholog: G5E9A8

TM-align score: 0.58 | RMSD: 2.46

Seq Identity: 0.03 | Length: 34 / 191

All Human Orthologs (OrthoMCL):

Gene ID	Description
ENSG00000101945	suppressor of variegation 3-9 homolog 1
ENSG00000119487	MAPK associated protein 1
ENSG00000152455	suppressor of variegation 3-9 homolog 2

Protein Information

Protein Length: 191 | Molecular Weight (kDa): 22.447

UniProt ID(s): Q8IIN9

PDB ID(s): None

Isoelectric Point: 4.83

Protein Domain Annotations:

Source	Family ID	Description
InterPro	IPR004365	OB-fold nucleic acid binding domain, AA-tRNA synthetase-type
InterPro	IPR012340	Nucleic acid-binding, OB-fold
PFam	PF01336	OB-fold nucleic acid binding domain, AA-tRNA synthetase-type
Superfamily	SSF50249	Nucleic acid-binding, OB-fold

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	2	9	9	11
disruptive	1	11	6	20
missense	1	11	6	16

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	3	20	6	12
disruptive	6	19	19	36
missense	4	16	16	27

PlasmoDB Total SNPs: 32

Non-coding: 23 | Synonymous: 8 | Nonsynonymous: 1 | Stop Codon: 0