PF3D7_1112500

Genome location: Pf3D7_11_v3:476,989..478,637(+)

Genome classification: Core

Function and Localization

Product Description: RNA transcription, translation and transport factor protein, putative

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	possibly expressed	0.24	0.88
Trophozoite	expressed	0.30	0.82
Schizont	not expressed	0.04	0.98
Gametocyte	possibly expressed	0.16	0.90

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1112500

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 0.133 | MFS: -3.178 | #Insertions: 1

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8IIN8

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_105549

Most Similar Human Ortholog: G3V4E7

TM-align score: 0.51 | RMSD: 2.97

Seq Identity: 0.24 | Length: 46 / 278

All Human Orthologs (OrthoMCL):

Gene ID	Description
ENSG00000087302	RNA transcription, translation and transport factor

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	7	14	8	21
disruptive	5	31	22	59
missense	5	28	22	50

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	9	30	14	17
disruptive	13	82	30	71
missense	10	68	24	51

PlasmoDB Total SNPs: 84

Non-coding: 58 | Synonymous: 17 | Nonsynonymous: 9 | Stop Codon: 0

Protein Information

Protein Length: 278 | Molecular Weight (kDa): 33.661

UniProt ID(s): Q8IIN8

PDB ID(s): None

Isoelectric Point: 4.99

Protein Domain Annotations:

Source	Family ID	Description
InterPro	IPR019265	RNA transcription, translation and transport factor protein
PFam	PF10036	RNA transcription, translation and transport factor protein
Superfamily	N/A	N/A