PF3D7_1112700

Genome location: Pf3D7_11_v3:481,830..485,831(+)

Genome classification: Core

Function and Localization

Product Description: conserved Plasmodium protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	not expressed	0.04	0.98
Trophozoite	not expressed	0.13	0.92
Schizont	not expressed	0.15	0.90
Gametocyte	not expressed	0.42	0.76

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1112700

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 1 | MFS: -0.655 | #Insertions: 19

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8IIN6

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_104125

Most Similar Human Ortholog: Q86Y56

TM-align score: 0.78 | RMSD: 4.78

Seq Identity: 0.12 | Length: 795 / 1159

All Human Orthologs (OrthoMCL):

Gene ID	Description
ENSG00000164818	dynein axonemal assembly factor 5

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	13	47	22	71
disruptive	47	133	86	188
missense	41	132	83	177

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	18	80	49	81
disruptive	79	259	134	263
missense	64	235	121	231

PlasmoDB Total SNPs: 167

Non-coding: 47 | Synonymous: 59 | Nonsynonymous: 61 | Stop Codon: 0

Protein Information

Protein Length: 1159 | Molecular Weight (kDa): 139.228

UniProt ID(s): Q8IIN6

PDB ID(s): None

Isoelectric Point: 7.23

Protein Domain Annotations:

Source	Family ID	Description
InterPro	IPR016024	Armadillo-type fold
PFam	N/A	N/A
Superfamily	SSF48371	Armadillo-type fold