PF3D7_1112800

Genome location: Pf3D7_11_v3:486,329..487,666(+)

Genome classification: Core

Function and Localization

Product Description: conserved protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	not expressed	0.02	0.99
Trophozoite	not expressed	0.06	0.96
Schizont	not expressed	0.08	0.95
Gametocyte	not expressed	0.16	0.91

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1112800

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 1 | MFS: -1.219 | #Insertions: 6

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8IIN5

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_130795

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	2	19	9	30
disruptive	14	41	25	68
missense	8	26	17	53

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	7	35	16	36
disruptive	25	88	45	105
missense	10	60	36	74

PlasmoDB Total SNPs: 62

Non-coding: 0 | Synonymous: 43 | Nonsynonymous: 17 | Stop Codon: 2

Protein Information

Protein Length: 445 | Molecular Weight (kDa): 52.8

UniProt ID(s): Q8IIN5

PDB ID(s): None

Isoelectric Point: 10.22

Protein Domain Annotations:

Source	Family ID	Description
InterPro	IPR012548	Protein of unknown function DUF1704
PFam	PF08014	Protein of unknown function DUF1704
Superfamily	N/A	N/A