PF3D7_1112900

Genome location: Pf3D7_11_v3:487,814..490,238(-)

Genome classification: Core

Function and Localization

Product Description: conserved protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	not expressed	0.01	1.00
Trophozoite	not expressed	0.01	1.00
Schizont	not expressed	0.31	0.80
Gametocyte	not expressed	0.61	0.72

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1112900

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 0.347 | MFS: -2.471 | #Insertions: 1

PlasmoGEM Phenotype: Dispensable (Pb ortholog: PBANKA_0934700)

Relative Growth Rate: 0.95 ± 0.25
Confidence: 4.15

RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_0934700)

Modification: Disrupted | RMgm-2653

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: A0A143ZZU6

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_533569

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	2	11	10	20
disruptive	3	26	24	51
missense	3	26	23	47

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	4	26	17	27
disruptive	9	76	40	100
missense	6	64	36	76

PlasmoDB Total SNPs: 103

Non-coding: 94 | Synonymous: 1 | Nonsynonymous: 8 | Stop Codon: 0

Protein Information

Protein Length: 363 | Molecular Weight (kDa): 43.753

UniProt ID(s): A0A143ZZU6

PDB ID(s): None

Isoelectric Point: 8.67

Protein Domain Annotations:

Source	Family ID	Description
InterPro	N/A	N/A
PFam	N/A	N/A
Superfamily	N/A	N/A