Product Description: protein tyrosine phosphatase
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: 3.1.3.48 (Protein-tyrosine-phosphatase)
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0009986 | cell surface |
| Component | GO:0005737 | cytoplasm |
| Component | GO:0020009 | microneme |
| Component | GO:0005634 | nucleus |
| Component | GO:0020008 | rhoptry |
| Function | GO:0004725 | protein tyrosine phosphatase activity |
| Process | GO:0018342 | protein prenylation |
| Process | GO:0009410 | response to xenobiotic stimulus |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | expressed | N/A | N/A |
| Ring | expressed | 0.78 | 0.62 |
| Trophozoite | expressed | 0.54 | 0.69 |
| Schizont | expressed | 0.81 | 0.54 |
| Gametocyte | expressed | 0.54 | 0.69 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_1113100
Resistome Missense Mutations: E201K
Resistome Compounds with Missense Mutations: MMV009108
Resistome # Samples with Disruptive Mutations: 3 (3 missense, 3 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS
MIS: 0.133 | MFS: -2.801 | #Insertions: 0
PlasmoGEM Phenotype: N/A
RMgmDB ABS Phenotype: Not tested (Pb ortholog: PBANKA_0934500)
Modification: Tagged | RMgm-1086
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q8IIN1
"Best" AlphaFill ligand hit: 4NP (4-nitrophenyl phosphate, Local RMSD=0.64) with 2I6P (Global RMSD=2.98)
BRENDA EC Inhibitors:
| EC # | Name | EC Inhibitors |
|---|---|---|
| 3.1.3.48 | protein-tyrosine-phosphatase | BRENDA SOAP query unsuccessful |
Orthology to BindingDB Entries:
| UniProt | Protein Name | Species | Homology Source | BindingDB Ligands |
|---|---|---|---|---|
| Q93096 | Protein tyrosine phosphatase type IVA 1 | Homo sapiens | OMA | CHEMBL3393171CHEMBL1088572US10308663, JMS-631-053MLS000028738... |
| O75365 | Protein tyrosine phosphatase type IVA 3 | Homo sapiens | OrthoDB | CHEMBL3393171US10308663, JMS-631-053CHEMBL3393171CHEMBL3393171... |
| Q12974 | Protein tyrosine phosphatase type IVA 2 | Homo sapiens | OrthoDB | CHEMBL3393171CHEMBL1088572CHEMBL3393171US10308663, JMS-631-053... |
Ortholog Group (OrthoMCL): OG6_101823
Most Similar Human Ortholog: E9PMY3
TM-align score: 0.90 | RMSD: 1.51
Seq Identity: 0.35 | Length: 63 / 218
All Human Orthologs (OrthoMCL):
| Gene ID | Description |
|---|---|
| ENSG00000112245 | protein tyrosine phosphatase 4A1 |
| ENSG00000184007 | protein tyrosine phosphatase 4A2 |
| ENSG00000184489 | protein tyrosine phosphatase 4A3 |
| ENSG00000275575 | protein tyrosine phosphatase 4A3 |
Protein Length: 218 | Molecular Weight (kDa): 25.102
PDB ID(s): None
Isoelectric Point: 8.16
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR000340 | Dual specificity phosphatase, catalytic domain |
| InterPro | IPR020422 | Dual specificity protein phosphatase domain |
| InterPro | IPR029021 | Protein-tyrosine phosphatase-like |
| PFam | PF00782 | Dual specificity phosphatase, catalytic domain |
| Superfamily | SSF52799 | Protein-tyrosine phosphatase-like |
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
No passing variants found
PlasmoDB Total SNPs: 273
Non-coding: 259 | Synonymous: 13 | Nonsynonymous: 1 | Stop Codon: 0
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 12368864 | Genome sequence of the human malaria parasite Plasmodium falciparum. | Gardner MJ, Hall N, ..., Barrell B | 10.1038/nature01097 |
| 18096253 | Characterization of a PRL protein tyrosine phosphatase from Plasmodiumfalciparum. | Pendyala PR, Ayong L, ..., Chakrabarti D | 10.1016/j.molbiopara.2007.11.006 |
| 25011111 | Genome-wide functional analysis of Plasmodium protein phosphatases reveals keyregulators of parasite development and differentiation. | Guttery DS, Poulin B, ..., Tewari R | 10.1016/j.chom.2014.05.020 |
| 33934569 | A Plasmodium falciparum protein tyrosine phosphatase inhibitor identified fromthe ChEMBL-NTD database blocks parasite growth. | Pandey R, Gupta P, ..., Gupta D | 10.1002/2211-5463.13171 |