About Gene List

PF3D7_1113300 (UGT)

Genome location: Pf3D7_11_v3:518,688..520,690(+)

Genome classification: Core

Function and Localization

Product Description: UDP-galactose transporter, putative

SignalP Peptide: N/A

# Transmembrane Domains: 8

EC Numbers: None

Curated GO (PlasmoDB):

Type GO Term Name
Component GO:0005783 endoplasmic reticulum
Component GO:0030173 integral component of Golgi membrane
Component GO:0030176 integral component of endoplasmic reticulum membrane
Component GO:0016020 membrane
Function GO:0005459 UDP-galactose transmembrane transporter activity
Function GO:0005460 UDP-glucose transmembrane transporter activity
Function GO:0022857 transmembrane transporter activity
Process GO:0072334 UDP-galactose transmembrane transport
Process GO:0009410 response to xenobiotic stimulus

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage LR class MCA mean MCA prop. zeros
Sporozoite not expressed N/A N/A
Ring possibly expressed 0.08 0.96
Trophozoite expressed 0.54 0.69
Schizont expressed 0.37 0.77
Gametocyte expressed 0.30 0.82

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1113300

Resistome Missense Mutations: F37V

Resistome Compounds with Missense Mutations: GNF179/KAF179

Resistome # Samples with Disruptive Mutations: 7 (7 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.121 | MFS: -3.023 | #Insertions: 0

PlasmoGEM Phenotype: Essential (Pb ortholog: PBANKA_0934300)

  • Relative Growth Rate: 0.11 ± 0.08
  • Confidence: 6.49

RMgmDB ABS Phenotype: Not different from wild type (Pb ortholog: PY17X_0936300)

Modification: Disrupted | RMgm-4767

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8IIM9

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_101710

Most Similar Human Ortholog: P78383

TM-align score: 0.87 | RMSD: 2.54

Seq Identity: 0.30 | Length: 305 / 343

All Human Orthologs (OrthoMCL):

Gene ID Description
ENSG00000121073 solute carrier family 35 member B1

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type common rare doubleton singleton
synonymous 3 20 13 24
disruptive 5 9 9 31
missense 5 9 9 26

Any inclusion in genotype call

variant type common rare doubleton singleton
synonymous 4 49 10 19
disruptive 11 37 28 65
missense 7 28 21 42

PlasmoDB Total SNPs: 100

Non-coding: 75 | Synonymous: 21 | Nonsynonymous: 4 | Stop Codon: 0

Protein Information

Protein Length: 343 | Molecular Weight (kDa): 39.425

UniProt ID(s): Q70XC2, Q8IIM9

PDB ID(s): None

Isoelectric Point: 10.04

Protein Domain Annotations:

Source Family ID Description
InterPro IPR013657 UAA transporter
PFam PF08449 UAA transporter
Superfamily SSF103481 N/A

Associated Publications

PMID Title Authors DOI/Link
12368864 Genome sequence of the human malaria parasite Plasmodium falciparum. Gardner MJ, Hall N, ..., Barrell B 10.1038/nature01097
27642791 UDP-galactose and acetyl-CoA transporters as Plasmodium multidrug resistancegenes. Lim MY, LaMonte G, ..., Bifani P 10.1038/nmicrobiol.2016.166