Product Description: UDP-galactose transporter, putative
SignalP Peptide: N/A
# Transmembrane Domains: 8
EC Numbers: None
Curated GO (PlasmoDB):
Type | GO Term | Name |
---|---|---|
Component | GO:0005783 | endoplasmic reticulum |
Component | GO:0030173 | integral component of Golgi membrane |
Component | GO:0030176 | integral component of endoplasmic reticulum membrane |
Component | GO:0016020 | membrane |
Function | GO:0005459 | UDP-galactose transmembrane transporter activity |
Function | GO:0005460 | UDP-glucose transmembrane transporter activity |
Function | GO:0022857 | transmembrane transporter activity |
Process | GO:0072334 | UDP-galactose transmembrane transport |
Process | GO:0009410 | response to xenobiotic stimulus |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
Stage | LR class | MCA mean | MCA prop. zeros |
---|---|---|---|
Sporozoite | not expressed | N/A | N/A |
Ring | possibly expressed | 0.08 | 0.96 |
Trophozoite | expressed | 0.54 | 0.69 |
Schizont | expressed | 0.37 | 0.77 |
Gametocyte | expressed | 0.30 | 0.82 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_1113300
Resistome Missense Mutations: F37V
Resistome Compounds with Missense Mutations: GNF179/KAF179
Resistome # Samples with Disruptive Mutations: 7 (7 missense, 0 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS
MIS: 0.121 | MFS: -3.023 | #Insertions: 0
PlasmoGEM Phenotype: Essential (Pb ortholog: PBANKA_0934300)
RMgmDB ABS Phenotype: Not different from wild type (Pb ortholog: PY17X_0936300)
Modification: Disrupted | RMgm-4767
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q8IIM9
"Best" AlphaFill ligand hit: No AlphaFill hits
No associated EC numbersNo evidence of orthology to BindingDB entries
Ortholog Group (OrthoMCL): OG6_101710
Most Similar Human Ortholog: P78383
TM-align score: 0.87 | RMSD: 2.54
Seq Identity: 0.30 | Length: 305 / 343
All Human Orthologs (OrthoMCL):
Gene ID | Description |
---|---|
ENSG00000121073 | solute carrier family 35 member B1 |
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
variant type | common | rare | doubleton | singleton |
---|---|---|---|---|
synonymous | 3 | 20 | 13 | 24 |
disruptive | 5 | 9 | 9 | 31 |
missense | 5 | 9 | 9 | 26 |
Any inclusion in genotype call
variant type | common | rare | doubleton | singleton |
---|---|---|---|---|
synonymous | 4 | 49 | 10 | 19 |
disruptive | 11 | 37 | 28 | 65 |
missense | 7 | 28 | 21 | 42 |
PlasmoDB Total SNPs: 100
Non-coding: 75 | Synonymous: 21 | Nonsynonymous: 4 | Stop Codon: 0
PMID | Title | Authors | DOI/Link |
---|---|---|---|
12368864 | Genome sequence of the human malaria parasite Plasmodium falciparum. | Gardner MJ, Hall N, ..., Barrell B | 10.1038/nature01097 |
27642791 | UDP-galactose and acetyl-CoA transporters as Plasmodium multidrug resistancegenes. | Lim MY, LaMonte G, ..., Bifani P | 10.1038/nmicrobiol.2016.166 |