Product Description: GTP-binding protein, putative
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0005737 | cytoplasm |
| Component | GO:0005739 | mitochondrion |
| Function | GO:0043022 | ribosome binding |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | not expressed | N/A | N/A |
| Ring | not expressed | 0.14 | 0.92 |
| Trophozoite | not expressed | 0.18 | 0.89 |
| Schizont | not expressed | 0.10 | 0.92 |
| Gametocyte | not expressed | 0.17 | 0.90 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_1113500
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Mutable in CDS
MIS: 0.998 | MFS: -1.91 | #Insertions: 2
PlasmoGEM Phenotype: Essential (Pb ortholog: PBANKA_0934100)
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q8IIM7
"Best" AlphaFill ligand hit: GCP (phosphomethylphosphonic acid guanylate ester, Local RMSD=0.37) with 3I92 (Global RMSD=6.43)
No associated EC numbersNo evidence of orthology to BindingDB entries
Ortholog Group (OrthoMCL): OG6_101542
Most Similar Human Ortholog: O43824
TM-align score: 0.72 | RMSD: 3.86
Seq Identity: 0.24 | Length: 427 / 698
All Human Orthologs (OrthoMCL):
| Gene ID | Description |
|---|---|
| ENSG00000178605 | GTP binding protein 6 (putative) |
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 8 | 40 | 21 | 34 |
| disruptive | 19 | 88 | 46 | 134 |
| missense | 19 | 87 | 46 | 116 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 13 | 74 | 22 | 43 |
| disruptive | 41 | 169 | 92 | 199 |
| missense | 39 | 148 | 82 | 134 |
PlasmoDB Total SNPs: 120
Non-coding: 72 | Synonymous: 28 | Nonsynonymous: 20 | Stop Codon: 0
Protein Length: 698 | Molecular Weight (kDa): 81.678
UniProt ID(s): Q8IIM7
PDB ID(s): None
Isoelectric Point: 8.57
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR006073 | GTP binding domain |
| InterPro | IPR016496 | GTPase HflX |
| InterPro | IPR025121 | GTPase HflX, N-terminal |
| InterPro | IPR027417 | P-loop containing nucleoside triphosphate hydrolase |
| PFam | PF01926 | GTP binding domain |
| PFam | PF13167 | GTPase HflX, N-terminal |
| Superfamily | SSF52540 | P-loop containing nucleoside triphosphate hydrolase |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 12368864 | Genome sequence of the human malaria parasite Plasmodium falciparum. | Gardner MJ, Hall N, ..., Barrell B | 10.1038/nature01097 |
| 34494883 | A Prioritized and Validated Resource of Mitochondrial Proteins in PlasmodiumIdentifies Unique Biology. | van Esveld SL, Meerstein-Kessel L, ..., Huynen MA | 10.1128/mSphere.00614-21 |