About Gene List

PF3D7_1113600

Genome location: Pf3D7_11_v3:526,884..529,092(+)

Genome classification: Core

Function and Localization

Product Description: conserved Plasmodium protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: 3.1.26.5 (Ribonuclease P)

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage LR class MCA mean MCA prop. zeros
Sporozoite possibly expressed N/A N/A
Ring expressed 0.37 0.82
Trophozoite expressed 0.44 0.74
Schizont expressed 0.10 0.93
Gametocyte possibly expressed 0.11 0.93

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1113600

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 0.79 | MFS: -3.022 | #Insertions: 1

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_0934000)

Modification: Disrupted | RMgm-2650

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8IIM6

"Best" AlphaFill ligand hit: No AlphaFill hits

BRENDA EC Inhibitors:

EC # Name EC Inhibitors
3.1.26.5 ribonuclease P ATPRNAEDTANH4+tRNASO42-NeoR5NeoG6NeoK6retinolneaminemat-tRNA...

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_532400

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type common rare doubleton singleton
synonymous 20 20 6 31
disruptive 22 78 36 96
missense 14 49 26 73

Any inclusion in genotype call

variant type common rare doubleton singleton
synonymous 25 34 16 27
disruptive 39 156 63 112
missense 22 105 44 75

PlasmoDB Total SNPs: 126

Non-coding: 70 | Synonymous: 42 | Nonsynonymous: 14 | Stop Codon: 0

Protein Information

Protein Length: 376 | Molecular Weight (kDa): 43.942

UniProt ID(s): Q8IIM6

PDB ID(s): None

Isoelectric Point: 8.03

Protein Domain Annotations:

Source Family ID Description
InterPro N/A N/A
PFam N/A N/A
Superfamily N/A N/A

Associated Publications

PMID Title Authors DOI/Link
12368864 Genome sequence of the human malaria parasite Plasmodium falciparum. Gardner MJ, Hall N, ..., Barrell B 10.1038/nature01097
16267556 A protein interaction network of the malaria parasite Plasmodium falciparum. LaCount DJ, Vignali M, ..., Hughes RE 10.1038/nature04104