PF3D7_1113800

Genome location: Pf3D7_11_v3:530,740..533,858(-)

Genome classification: Core

Function and Localization

Product Description: conserved Plasmodium membrane protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 6

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	possibly expressed	0.07	0.97
Trophozoite	expressed	0.64	0.64
Schizont	expressed	0.47	0.72
Gametocyte	expressed	0.36	0.79

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1113800

Resistome Missense Mutations: L476F

Resistome Compounds with Missense Mutations: MMV982556

Resistome # Samples with Disruptive Mutations: 2 (2 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.12 | MFS: -3.023 | #Insertions: 0

PlasmoGEM Phenotype: Dispensable (Pb ortholog: PBANKA_0933800)

Relative Growth Rate: 0.96 ± 0.10
Confidence: 5.97

RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_0933800)

Modification: Disrupted | RMgm-2648

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8IIM4

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_142855

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	3	22	21	25
disruptive	7	38	30	66
missense	4	36	28	60

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	6	53	23	40
disruptive	11	98	53	112
missense	7	75	46	82

PlasmoDB Total SNPs: 110

Non-coding: 89 | Synonymous: 15 | Nonsynonymous: 6 | Stop Codon: 0

Protein Information

Protein Length: 702 | Molecular Weight (kDa): 85.752

UniProt ID(s): Q8IIM4

PDB ID(s): None

Isoelectric Point: 9.52

Protein Domain Annotations:

Source	Family ID	Description
InterPro	N/A	N/A
PFam	N/A	N/A
Superfamily	N/A	N/A