About Gene List

PF3D7_1114200

Genome location: Pf3D7_11_v3:542,108..546,077(-)

Genome classification: Core

Function and Localization

Product Description: GTPase-activating protein, putative

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB):

Type GO Term Name
Component GO:0020036 Maurer's cleft
Function GO:0005096 GTPase activator activity
Process GO:0090630 activation of GTPase activity
Process GO:0006886 intracellular protein transport

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage LR class MCA mean MCA prop. zeros
Sporozoite not expressed N/A N/A
Ring expressed 0.76 0.64
Trophozoite not expressed 0.31 0.82
Schizont not expressed 0.10 0.94
Gametocyte not expressed 0.36 0.79

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1114200

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.218 | MFS: -3.46 | #Insertions: 0

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8IIL9

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_100958

Most Similar Human Ortholog: Q5TC63

TM-align score: 0.91 | RMSD: 1.81

Seq Identity: 0.33 | Length: 323 / 373

All Human Orthologs (OrthoMCL):

Gene ID Description
ENSG00000095383 TBC1 domain family member 2
ENSG00000139835 growth hormone regulated TBC protein 1
ENSG00000167202 TBC1 domain family member 2B

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

No passing variants found

PlasmoDB Total SNPs: 255

Non-coding: 245 | Synonymous: 10 | Nonsynonymous: 0 | Stop Codon: 0

Protein Information

Protein Length: 373 | Molecular Weight (kDa): 44.608

UniProt ID(s): Q8IIL9

PDB ID(s): None

Isoelectric Point: 9.02

Protein Domain Annotations:

Source Family ID Description
InterPro IPR000195 Rab-GTPase-TBC domain
InterPro IPR035969 Rab-GTPase-TBC domain superfamily
PFam PF00566 Rab-GTPase-TBC domain
Superfamily SSF47923 Rab-GTPase-TBC domain superfamily

Associated Publications

PMID Title Authors DOI/Link
12368864 Genome sequence of the human malaria parasite Plasmodium falciparum. Gardner MJ, Hall N, ..., Barrell B 10.1038/nature01097
31631203 A network-based approach reveals novel invasion and Maurer's clefts-relatedproteins in Plasmodium falciparum. Das D, Krishnan SR, Roy A, Bulusu G 10.1039/c9mo00124g