About Gene List

PF3D7_1114400

Genome location: Pf3D7_11_v3:547,383..549,296(-)

Genome classification: Core

Function and Localization

Product Description: RAP protein, putative

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB):

Type GO Term Name
Component GO:0005739 mitochondrion

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage LR class MCA mean MCA prop. zeros
Sporozoite not expressed N/A N/A
Ring not expressed 0.05 0.98
Trophozoite not expressed 0.31 0.81
Schizont not expressed 0.08 0.95
Gametocyte not expressed 0.19 0.89

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1114400

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.119 | MFS: -3.162 | #Insertions: 0

PlasmoGEM Phenotype: Essential (Pb ortholog: PBANKA_0933300)

  • Relative Growth Rate: 0.09 ± 0.06
  • Confidence: 7.09

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8IIL8

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_156395

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type common rare doubleton singleton
synonymous 2 24 15 37
disruptive 12 48 35 119
missense 12 48 35 110

Any inclusion in genotype call

variant type common rare doubleton singleton
synonymous 6 51 30 42
disruptive 25 122 82 142
missense 20 108 80 109

PlasmoDB Total SNPs: 42

Non-coding: 0 | Synonymous: 26 | Nonsynonymous: 15 | Stop Codon: 1

Protein Information

Protein Length: 637 | Molecular Weight (kDa): 77.377

UniProt ID(s): Q8IIL8

PDB ID(s): None

Isoelectric Point: 9.26

Protein Domain Annotations:

Source Family ID Description
InterPro IPR013584 RAP domain
PFam N/A N/A
Superfamily N/A N/A

Associated Publications

PMID Title Authors DOI/Link
12368864 Genome sequence of the human malaria parasite Plasmodium falciparum. Gardner MJ, Hall N, ..., Barrell B 10.1038/nature01097
30204084 Elucidating the mitochondrial proteome of Toxoplasma gondii reveals the presenceof a divergent cytochrome c oxidase Seidi A, Muellner-Wong LS, ..., van Dooren GG 10.7554/eLife.38131
34494883 A Prioritized and Validated Resource of Mitochondrial Proteins in PlasmodiumIdentifies Unique Biology. van Esveld SL, Meerstein-Kessel L, ..., Huynen MA 10.1128/mSphere.00614-21