PF3D7_1114600

Genome location: Pf3D7_11_v3:552,259..553,266(+)

Genome classification: Core

Function and Localization

Product Description: conserved Plasmodium protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	possibly expressed	0.02	0.99
Trophozoite	not expressed	0.04	0.98
Schizont	not expressed	0.02	0.98
Gametocyte	possibly expressed	0.15	0.91

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1114600

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 1 | MFS: -2.644 | #Insertions: 1

PlasmoGEM Phenotype: Essential (Pb ortholog: PBANKA_0933100)

Relative Growth Rate: 0.03 ± 0.08
Confidence: 6.52

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8IIL6

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_532911

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	3	14	5	18
disruptive	9	32	30	71
missense	9	32	26	65

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	5	27	9	24
disruptive	20	113	54	93
missense	12	97	51	65

PlasmoDB Total SNPs: 15

Non-coding: 0 | Synonymous: 7 | Nonsynonymous: 8 | Stop Codon: 0

Protein Information

Protein Length: 335 | Molecular Weight (kDa): 39.591

UniProt ID(s): Q8IIL6

PDB ID(s): None

Isoelectric Point: 8.9

Protein Domain Annotations:

Source	Family ID	Description
InterPro	N/A	N/A
PFam	N/A	N/A
Superfamily	N/A	N/A