PF3D7_1114900

Genome location: Pf3D7_11_v3:561,660..569,505(+)

Genome classification: Core

Function and Localization

Product Description: filamin domain-containing protein, putative

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB):

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

More info:

• Malaria Parasite Metabolic Pathways (MPMP) Link
• BiGG Metabolic Model Link
• STRING Interaction Network Link

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1114900

Resistome Missense Mutations: C575F

Resistome Compounds with Missense Mutations: MMV020746

Resistome # Samples with Disruptive Mutations: 1 (1 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.138 | MFS: -2.828 | #Insertions: 0

PlasmoGEM Phenotype: Essential (Pb ortholog: PBANKA_0932800)

• Relative Growth Rate: 0.11 ± 0.12
• Confidence: 5.67

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8IIL3

"Best" AlphaFill ligand hit: FMN (flavin mononucleotide, Local RMSD=0.22) with 1TV5 (Global RMSD=18.21)

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_139463

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

Any inclusion in genotype call

PlasmoDB Total SNPs: 318

Non-coding: 33 | Synonymous: 202 | Nonsynonymous: 82 | Stop Codon: 1

Protein Information

Protein Length: 2480 | Molecular Weight (kDa): 295.379

UniProt ID(s): Q8IIL3

PDB ID(s): None

Isoelectric Point: 8.05

Protein Domain Annotations: