PF3D7_1115000

Genome location: Pf3D7_11_v3:569,509..570,889(+)

Genome classification: Core

Function and Localization

Product Description: conserved protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	expressed	N/A	N/A
Ring	possibly expressed	0.05	0.98
Trophozoite	expressed	0.47	0.71
Schizont	expressed	0.07	0.95
Gametocyte	expressed	0.17	0.90

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1115000

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS *tentative

MIS: 0.12 | MFS: -3.137 | #Insertions: 0

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8IIL2

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_179342

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	2	9	4	8
disruptive	1	10	10	20
missense	1	10	10	17

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	4	17	1	12
disruptive	5	22	15	39
missense	2	21	12	29

PlasmoDB Total SNPs: 119

Non-coding: 114 | Synonymous: 5 | Nonsynonymous: 0 | Stop Codon: 0

Protein Information

Protein Length: 145 | Molecular Weight (kDa): 18.438

UniProt ID(s): Q8IIL2

PDB ID(s): None

Isoelectric Point: 10.77

Protein Domain Annotations:

Source	Family ID	Description
InterPro	N/A	N/A
PFam	N/A	N/A
Superfamily	N/A	N/A