PF3D7_1115100

Genome location: Pf3D7_11_v3:570,914..573,409(-)

Genome classification: Core

Function and Localization

Product Description: conserved protein, unknown function

SignalP Peptide: MRITFVKIINCFSYYLLIQLCLFKSCLN

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	not expressed	0.00	1.00
Trophozoite	not expressed	0.01	0.99
Schizont	not expressed	0.01	1.00
Gametocyte	expressed	0.29	0.84

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1115100

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 0.934 | MFS: -2.623 | #Insertions: 1

PlasmoGEM Phenotype: Dispensable (Pb ortholog: PBANKA_0932600)

Relative Growth Rate: 1.06 ± 0.07
Confidence: 6.57

RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_0932600)

Modification: Disrupted | RMgm-2640

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: C6S3F1

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_139462

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	6	24	12	25
disruptive	5	34	15	44
missense	5	34	15	43

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	10	45	11	29
disruptive	9	64	23	68
missense	8	63	21	58

PlasmoDB Total SNPs: 154

Non-coding: 139 | Synonymous: 8 | Nonsynonymous: 7 | Stop Codon: 0

Protein Information

Protein Length: 307 | Molecular Weight (kDa): 34.566

UniProt ID(s): C6S3F1

PDB ID(s): None

Isoelectric Point: 9.39

Protein Domain Annotations:

Source	Family ID	Description
InterPro	N/A	N/A
PFam	N/A	N/A
Superfamily	N/A	N/A