About Gene List

PF3D7_1115200 (SET7)

Genome location: Pf3D7_11_v3:574,690..580,622(+)

Genome classification: Core

Function and Localization

Product Description: histone-lysine N-methyltransferase SET7

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: 2.1.1.43 (Transferred entry: 2.1.1.354)

Curated GO (PlasmoDB):

Type GO Term Name
Component GO:0005737 cytoplasm
Component GO:0005634 nucleus
Function GO:0042800 histone methyltransferase activity (H3-K4 specific)
Function GO:0046974 histone methyltransferase activity (H3-K9 specific)
Function GO:0018024 histone-lysine N-methyltransferase activity
Process GO:0051568 histone H3-K4 methylation
Process GO:0051567 histone H3-K9 methylation
Process GO:0034968 histone lysine methylation

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage LR class MCA mean MCA prop. zeros
Sporozoite expressed N/A N/A
Ring expressed 0.26 0.87
Trophozoite expressed 0.35 0.78
Schizont expressed 0.63 0.64
Gametocyte expressed 0.97 0.54

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1115200

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS *tentative

MIS: 0.983 | MFS: -2.078 | #Insertions: 0

PlasmoGEM Phenotype: Slow (Pb ortholog: PBANKA_0932500)

  • Relative Growth Rate: 0.52 ± 0.20
  • Confidence: 4.64

RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_0932500)

Modification: Disrupted | RMgm-2639

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8IIL1

"Best" AlphaFill ligand hit: SFG (sinefungin, Local RMSD=0.47) with 3N71 (Global RMSD=6.59)

BRENDA EC Inhibitors:

EC # Name EC Inhibitors
2.1.1.43 histone-lysine N-methyltransferase BRENDA SOAP query unsuccessful

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_119251

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type common rare doubleton singleton
synonymous 5 36 25 60
disruptive 26 102 43 127
missense 10 76 32 99

Any inclusion in genotype call

variant type common rare doubleton singleton
synonymous 11 77 32 52
disruptive 50 185 79 175
missense 22 139 57 122

PlasmoDB Total SNPs: 379

Non-coding: 282 | Synonymous: 57 | Nonsynonymous: 40 | Stop Codon: 0

Protein Information

Protein Length: 793 | Molecular Weight (kDa): 94.293

UniProt ID(s): Q8IIL1

PDB ID(s): None

Isoelectric Point: 4.2

Protein Domain Annotations:

Source Family ID Description
InterPro IPR001214 SET domain
PFam PF00856 SET domain
Superfamily SSF82199 N/A

Associated Publications

PMID Title Authors DOI/Link
12368864 Genome sequence of the human malaria parasite Plasmodium falciparum. Gardner MJ, Hall N, ..., Barrell B 10.1038/nature01097
16267556 A protein interaction network of the malaria parasite Plasmodium falciparum. LaCount DJ, Vignali M, ..., Hughes RE 10.1038/nature04104
26902486 Plasmodium falciparum PfSET7: enzymatic characterization and cellularlocalization of a novel protein methyltransferase in sporozoite, liver anderythrocytic stage parasites. Chen PB, Ding S, ..., Malmquist NA 10.1038/srep21802