PF3D7_1115600 (CYP19B)

Genome location: Pf3D7_11_v3:589,237..591,038(-)

Genome classification: Core

Function and Localization

Product Description: peptidyl-prolyl cis-trans isomerase

SignalP Peptide: MNKLVSIILVIFFLFHKYALC

# Transmembrane Domains: 0

EC Numbers: 5.2.1.8 (Peptidylprolyl isomerase)

Curated GO (PlasmoDB):

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

More info:

• Malaria Parasite Metabolic Pathways (MPMP) Link
• BiGG Metabolic Model Link
• STRING Interaction Network Link

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1115600

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 1 | MFS: 0.755 | #Insertions: 2

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: Not different from wild type (Pb ortholog: PBANKA_0932200)

Modification: Disrupted | RMgm-253

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8IIK8

"Best" AlphaFill ligand hit: LSA (saccharin, Local RMSD=0.06) with 4N1O (Global RMSD=1.38)

BRENDA EC Inhibitors:

Orthology to BindingDB Entries:

Orthology Information

Ortholog Group (OrthoMCL): OG6_100844

Most Similar Human Ortholog: A0A7P0Z497

TM-align score: 0.89 | RMSD: 1.49

Seq Identity: 0.51 | Length: 170 / 195

All Human Orthologs (OrthoMCL):

Protein Information

Protein Length: 195 | Molecular Weight (kDa): 21.731

UniProt ID(s): Q27745, Q8IIK8

PDB ID(s): None

Isoelectric Point: 7.51

Protein Domain Annotations:

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

Any inclusion in genotype call

PlasmoDB Total SNPs: 125

Non-coding: 119 | Synonymous: 3 | Nonsynonymous: 3 | Stop Codon: 0