Product Description: folate transporter 2
SignalP Peptide: N/A
# Transmembrane Domains: 11
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0045177 | apical part of cell |
| Component | GO:0020011 | apicoplast |
| Component | GO:0005886 | plasma membrane |
| Function | GO:0008517 | folic acid transmembrane transporter activity |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | expressed | N/A | N/A |
| Ring | expressed | 0.02 | 0.99 |
| Trophozoite | expressed | 0.13 | 0.91 |
| Schizont | expressed | 0.26 | 0.82 |
| Gametocyte | expressed | 0.17 | 0.89 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_1116500
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Mutable in CDS
MIS: 0.334 | MFS: -3.043 | #Insertions: 1
PlasmoGEM Phenotype: Dispensable (Pb ortholog: PBANKA_0931500)
RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_0931500)
Modification: Tagged | RMgm-4882
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q8IIK1
"Best" AlphaFill ligand hit: No AlphaFill hits
No associated EC numbersNo evidence of orthology to BindingDB entries
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 3 | 26 | 13 | 44 |
| disruptive | 1 | 3 | 8 | 13 |
| missense | 1 | 3 | 7 | 13 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 8 | 58 | 22 | 43 |
| disruptive | 5 | 24 | 24 | 72 |
| missense | 1 | 18 | 17 | 54 |
PlasmoDB Total SNPs: 305
Non-coding: 295 | Synonymous: 10 | Nonsynonymous: 0 | Stop Codon: 0
Protein Length: 455 | Molecular Weight (kDa): 51.355
UniProt ID(s): Q8IIK1
PDB ID(s): None
Isoelectric Point: 8.49
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR036259 | MFS transporter superfamily |
| InterPro | IPR039309 | Biopterin transporter family |
| PFam | PF03092 | Biopterin transporter family |
| Superfamily | SSF103473 | MFS transporter superfamily |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 11152613 | Predicting transmembrane protein topology with a hidden Markov model: applicationto complete genomes. | Krogh A, Larsson B, von Heijne G, Sonnhammer EL | 10.1006/jmbi.2000.4315 |
| 12368864 | Genome sequence of the human malaria parasite Plasmodium falciparum. | Gardner MJ, Hall N, ..., Barrell B | 10.1038/nature01097 |
| 21998306 | The molecular basis of folate salvage in Plasmodium falciparum: characterizationof two folate transporters. | Salcedo-Sora JE, Ochong E, ..., Ward SA | 10.1074/jbc.M111.286054 |
| 32975363 | An apicoplast-resident folate transporter is essential for sporogony of malariaparasites. | Korbmacher F, Drepper B, ..., Matz JM | 10.1111/cmi.13266 |