PF3D7_1116900

Genome location: Pf3D7_11_v3:644,100..645,537(-)

Genome classification: Core

Function and Localization

Product Description: conserved protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	no data	N/A	N/A
Ring	no data	0.00	1.00
Trophozoite	no data	0.01	0.99
Schizont	no data	0.11	0.93
Gametocyte	no data	0.35	0.81

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1116900

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 1 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.818 | MFS: -1.914 | #Insertions: 0

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: A0A144A0T9

"Best" AlphaFill ligand hit: SAH (s-adenosyl-l-homocysteine, Local RMSD=6.88) with 3BGV (Global RMSD=20.28)

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_160740

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	2	13	6	15
disruptive	3	5	6	16
missense	3	4	6	15

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	4	22	12	13
disruptive	6	21	17	39
missense	4	18	16	29

PlasmoDB Total SNPs: 120

Non-coding: 100 | Synonymous: 16 | Nonsynonymous: 4 | Stop Codon: 0

Protein Information

Protein Length: 212 | Molecular Weight (kDa): 23.64

UniProt ID(s): A0A144A0T9

PDB ID(s): None

Isoelectric Point: 7.58

Protein Domain Annotations:

Source	Family ID	Description
InterPro	N/A	N/A
PFam	N/A	N/A
Superfamily	N/A	N/A