PF3D7_1117000

Genome location: Pf3D7_11_v3:646,922..651,343(-)

Genome classification: Core

Function and Localization

Product Description: MFS domain-containing protein P115, putative

SignalP Peptide: N/A

# Transmembrane Domains: 14

EC Numbers: None

Curated GO (PlasmoDB):

Type	GO Term	Name
Component	GO:0005886	plasma membrane

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	possibly expressed	N/A	N/A
Ring	expressed	0.02	0.99
Trophozoite	expressed	0.13	0.91
Schizont	expressed	0.07	0.95
Gametocyte	expressed	0.34	0.80

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1117000

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 1 | MFS: -1.25 | #Insertions: 4

PlasmoGEM Phenotype: Dispensable (Pb ortholog: PBANKA_0931000)

Relative Growth Rate: 0.93 ± 0.12
Confidence: 5.55

RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_0931000)

Modification: Tagged | RMgm-4687

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8IIJ7

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_533206

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	14	54	30	76
disruptive	29	153	80	192
missense	22	137	78	163

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	27	107	44	90
disruptive	59	320	156	333
missense	41	267	133	252

PlasmoDB Total SNPs: 240

Non-coding: 79 | Synonymous: 79 | Nonsynonymous: 78 | Stop Codon: 4

Protein Information

Protein Length: 1283 | Molecular Weight (kDa): 153.076

UniProt ID(s): Q8IIJ7

PDB ID(s): None

Isoelectric Point: 7.63

Protein Domain Annotations:

Source	Family ID	Description
InterPro	IPR036259	MFS transporter superfamily
PFam	N/A	N/A
Superfamily	SSF103473	MFS transporter superfamily

PMID	Title	Authors	DOI/Link
11152613	Predicting transmembrane protein topology with a hidden Markov model: applicationto complete genomes.	Krogh A, Larsson B, von Heijne G, Sonnhammer EL	10.1006/jmbi.2000.4315
12368864	Genome sequence of the human malaria parasite Plasmodium falciparum.	Gardner MJ, Hall N, ..., Barrell B	10.1038/nature01097
31616399	An MFS-Domain Protein Pb115 Plays a Critical Role in Gamete Fertilization of theMalaria Parasite Plasmodium berghei.	Liu F, Liu Q, ..., Cao Y	10.3389/fmicb.2019.02193